Bevacizumab-loaded polyurethane subconjunctival implants: effects on experimental glaucoma filtration surgery.

Purpose: Vascular endothelial growth factor (VEGF) may contribute to the scarring process resulting from glaucoma filtration surgery, since this cytokine may stimulate fibroblast proliferation. The aim of this study was to describe a new bevacizumab-loaded polyurethane implant (BPUI) and to evaluate its effectiveness as a new drug delivery system of anti-VEGF antibody in a rabbit model of glaucoma filtration surgery.

Methods: An aqueous dispersion of polyurethane was obtained via the conventional process.