Publications by authors named "Robert da Silva Tiburcio"
Trypanosoma cruzi killing and immune response boosting by novel phenoxyhydrazine-thiazole against Chagas disease.
Ana Catarina Cristovão-Silva Maria Carolina Accioly Brelaz-de-Castro Elis Dionisio da Silva Ana Cristina Lima Leite Lizandra Beatriz Amorim Alves Santiago Robert da Silva Tiburcio
Exp Parasitol
June 2024
Article Synopsis
- T. cruzi causes Chagas disease, affecting 6-7 million people globally, and current treatments like benznidazole are highly toxic and only work in the acute phase.
- Researchers developed and analyzed thirteen new phenoxyhydrazine-thiazole compounds, demonstrating effective anti-T. cruzi activity with most showing low toxicity in mammalian cells.
- The compound LIZ311 emerged as a promising candidate, inducing significant immune responses without harming mammalian cells, and exhibiting potent effects against different life stages of T. cruzi.
To synthesize novel more potent trypanocidal and leishmanicidal agents. Hantzsch's synthetic strategy was used to synthesize 1,3-thiazole-4-carboxylates and their -benzylated derivatives. 28 new thiazole-carboxylates and their -benzylated derivatives were established to test their trypanocidal and leishmanicidal activities.
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