Publications by authors named "Robert Yl Tsai"
Article Synopsis
- Most low-grade oral epithelial dysplasia often stays the same or gets better, but a small percentage (4-11%) can develop into oral squamous cell carcinoma (OSCC) within a few years.
- Research was conducted on nucleostemin (NS) and phospho-STAT3 (p-STAT3) expression in rodent and human samples, finding that both markers increased in lesions compared to normal tissue, suggesting their involvement in cancer progression.
- In human studies, higher levels of NS and more intense p-STAT3 expression were linked to high-grade dysplasia and OSCC, with significant findings indicating that elevated NS signals in low-grade dysplasia can predict progression to OSCC within a short timeframe.
Neural stem cells (NSCs) exhibit preferential homing toward some types of brain lesion, but their migratory property during radiation brain injury (RBI) remains unexplored. Here, we use the superparamagnetic iron oxide (SPIO)-labeled magnetic resonance imaging (MRI) technology to determine the migration of transplanted NSCs in two partial RBI models in real time created by administering 30-55 Gy of radiation to the right or posterior half of the adult rat brain. SPIO-labeled NSCs were stereotactically grafted into the uninjured side one week after RBI.
View Article and Find Full Text PDFMost of the adult CNS lacks regenerative activity in terms of both neuron birth and neurite outgrowth. While this regeneration-unfriendly environment of the adult CNS may preserve the existing neuronal circuitry that takes years to develop in higher organisms, it also poses a major obstacle for CNS repair later in life. In this issue of the JCI, Song et al.
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