Modular and extendable 1D-simulation for microfluidic devices.

Microfluidic devices have been the subject of considerable attention in recent years. The development of novel microfluidic devices, their evaluation, and their validation requires simulations. While common methods based on Computational Fluid Dynamics (CFD) can be time-consuming, 1D simulation provides an appealing alternative that leads to efficient results with reasonable quality.

Model-driven engineering of safety and security software systems: A systematic mapping study and future research directions.

This article presents a systematic mapping study on the model-driven engineering of safety and security concerns in software systems. Combined modeling and development of both safety and security concerns is an emerging field of research as both concerns affect one another in unique ways. Our mapping study provides an overview of the current state of the art in this field.

Accelerated Computational Fluid Dynamics Simulations of Microfluidic Devices by Exploiting Higher Levels of Abstraction.

The design of microfluidic devices is a cumbersome and tedious process that can be significantly improved by simulation. Methods based on (CFD) are considered state-of-the-art, but require extensive compute time-oftentimes limiting the size of microfluidic devices that can be simulated. Simulation methods that abstract the underlying physics on a higher level generally provide results instantly, but the fidelity of these methods is usually worse.

Simulation of Pressure-Driven and Channel-Based Microfluidics on Different Abstract Levels: A Case Study.

A microfluidic device, or a Lab-on-a-Chip (LoC), performs lab operations on the microscale through the manipulation of fluids. The design and fabrication of such devices usually is a tedious process, and auxiliary tools, such as simulators, can alleviate the necessary effort for the design process. Simulations of fluids exist in various forms and can be categorized according to how well they represent the underlying physics, into so-called abstraction levels.

Off-Chip-Controlled Droplet-on-Demand Method for Precise Sample Handling.

We present a simple, stable, and highly reproducible off-chip-controlled method for generating droplets-on-demand. To induce the droplet generation, externally pre-programmed positive pressure pulses are applied to the dispersed phase input while the continuous phase channel remains at constant input pressure. By controlling solely one fluid phase, the method allows for connecting multiple independent dispersed-phase channels to a single continuous channel.

Meander Designer: Automatically Generating Meander Channel Designs.

Microfluidics continues to bring innovation to the life sciences. It stimulates progress by enabling new ways of research in biology, chemistry, and biotechnology. However, when designing a microfluidic device, designers have to conduct many tasks by hand-resulting in labor-intensive processes.

Simulation before fabrication: a case study on the utilization of simulators for the design of droplet microfluidic networks.

The functional performance of passively operated droplet microfluidics is sensitive with respect to the dimensions of the channel network, the fabrication precision as well as the applied pressure because the entire network is coupled together. Especially, the local and global hydrodynamic resistance changes caused by droplets make the task to develop a robust microfluidic design challenging as plenty of interdependencies which all affect the intended behavior have to be considered by the designer. After the design, its functionality is usually validated by fabricating a prototype and testing it with physical experiments.

Synthesis of Arbitrary Quantum Circuits to Topological Assembly: Systematic, Online and Compact.

It is challenging to transform an arbitrary quantum circuit into a form protected by surface code quantum error correcting codes (a variant of topological quantum error correction), especially if the goal is to minimise overhead. One of the issues is the efficient placement of magic state distillation sub circuits, so-called distillation boxes, in the space-time volume that abstracts the computation's required resources. This work presents a general, systematic, online method for the synthesis of such circuits.