Twisting: Incidence and Risk Factors of an Intraprocedural Challenge Associated With Pipeline Flow Diversion of Cerebral Aneurysms.

Background: Pipeline Embolization Device (PED; Medtronic) "twisting" manifests with the appearance of a "figure 8" in perpendicular planes on digital subtraction angiography. This phenomenon has received little attention in the literature, requires technical precision to remediate, and has potential to cause ischemic stroke if not properly remediated.

Objective: To report incidence, risk factors, and sequelae of PED twisting and to discuss techniques to remediate a PED twist.

Multiple pipeline twists encountered during treatment of a symptomatic fusiform ICA aneurysm.

Pipeline embolisation device (PED) 'twisting' is an intra-operative complication that manifests with the appearance of a 'figure-8' in perpendicular planes on digital subtraction angiography. A twisted PED causes narrowing and/or complete occlusion of the vessel lumen and poses significant risks for thrombus formation and downstream ischaemia. Here, we present a case in which three unique PED implants become twisted during pipeline embolisation of a large fusiform internal carotid artery aneurysm.

Aspirin Monotherapy in Flow Diversion of Selected Internal Carotid Artery Aneurysms.

Background: Dual antiplatelet therapy has been adopted as the standard of care for intracranial stenting, including flow diversion of cerebral aneurysms, to reduce the risk of acute and delayed ischemic complications.

Case Description: This is a report of 2 cases in which patients who underwent flow diversion of unruptured internal carotid artery aneurysms were treated with aspirin monotherapy. Neither patient tolerated dual antiplatelet therapy, one because of nosebleeds due to hereditary hemorrhagic telangiectasia and one because of an unnamed bleeding disorder.

Workshop Report on Atomic Bomb Dosimetry--Review of Dose Related Factors for the Evaluation of Exposures to Residual Radiation at Hiroshima and Nagasaki.

Groups of Japanese and American scientists, supported by international collaborators, have worked for many years to ensure the accuracy of the radiation dosimetry used in studies of health effects in the Japanese atomic bomb survivors. Reliable dosimetric models and systems are especially critical to epidemiologic studies of this population because of their importance in the development of worldwide radiation protection standards. While dosimetry systems, such as Dosimetry System 1986 (DS86) and Dosimetry System 2002 (DS02), have improved, the research groups that developed them were unable to propose or confirm an additional contribution by residual radiation to the survivor's total body dose.

Prevention of lung injury in cardiac surgery: a review.

Inflammatory lung injury is an inevitable consequence of cardiac surgery with cardiopulmonary bypass. The lungs are particularly susceptible to the effects of the systemic inflammatory response to cardiopulmonary bypass. This insult is further exacerbated by a pulmonary ischemia-reperfusion injury after termination of bypass.

Workshop report on atomic bomb dosimetry-residual radiation exposure: recent research and suggestions for future studies.

There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012.

Hyperoxia: a review of the risks and benefits in adult cardiac surgery.

Perioperative hyperoxia has been claimed to have a number of therapeutic advantages. However, in the setting of cardiac surgery and cardiopulmonary bypass (CPB), enthusiasm for its use has been tempered by concerns regarding the effect of high partial pressures of oxygen on cardiac, vascular, and respiratory function and the potential for exacerbation of ischemia-reperfusion injury. There is encouraging evidence from animal studies that hyperoxia is effective in myocardial preconditioning, at least in nondiseased hearts.

An efficient and inexpensive refrigerated LC system for H/D exchange mass spectrometry.

Loss of deuterium label during the LC step in amide hydrogen/deuterium exchange mass spectrometry (H/D-MS) is minimized by maintaining an acidic mobile phase pH and low temperature (pH 2.5, 0 °C). Here we detail the construction and performance of a low-cost, thermoelectrically refrigerated enclosure to house high-performance liquid chromatography (HPLC) components and cool mobile phases.

Anxiolytic effects of nicotine in a rodent test of approach-avoidance conflict.

Rationale: Nicotine has been reported to produce both anxiolytic and/or anxiogenic effects in humans and animals.

Objectives: This study examined whether pretreatment with nicotine would alter anxiety in a unique runway model of approach-avoidance conflict.

Materials And Methods: Food-restricted rats were trained to run a straight alley once a day to obtain food upon goal-box entry.

Development and validation of the Pain Outcomes Questionnaire-VA.

The development of effective pain treatment strategies requires the availability of precise and practical measures of treatment outcomes, the importance of which has been noted in the Veterans Health Administration's (VHA's) National Pain Initiative. This paper presents the results of a 5-year collaborative effort to develop and validate a comprehensive and efficient self-report measure of pain treatment outcomes. Two samples of veterans (957 total subjects) undergoing inpatient or outpatient pain treatment at six VHA facilities completed Pain Outcomes Questionnaire-VA (POQ-VA) items and several additional measures.

Detection of back random responding: effectiveness of MMPI-2 and Personality Assessment Inventory validity indices.

Two experiments examined the detection and effects of back random responding (BRR) on the Minnesota Multiphasic Personality Inventory--2 (MMPI-2) and the Personality Assessment Inventory (PAI). Experiment 1 revealed that MMPI-2 Clinical and Content scales were relatively resistant to the effects of BRR. Fb--F > or = 20T was the most effective index for identifying invalid protocols.

Psychological consequences of military operations in low-level radiation environments.

Military operations have produced neuropsychiatric (NP) casualties throughout history. The same is true for radiation accidents. Although we have not carried out military operations in nuclear environments, related experience suggests that operations performed under low-level radiation conditions could serve to compound the factors that are known to produce NP casualties.

Sonic booms of space shuttles approaching Edwards Air Force Base, 1988-1993.

From 1988 to 1993 13 sonic booms of space shuttles approaching Edwards Air Force Base were measured at a site 10 miles west of EAFB, with one to seven different sound level meters for each measurement. Results from five of these measurements are here presented. Maximum differences in measured levels between instruments for the same flight varied from 0 to 6 dB depending on the measurement descriptor and model of sound level meter.