Acceptance of a potential major bleeding among patients with venous thromboembolism on long-term oral anticoagulation: the knowledge of the disease and therapy matters.

Background: We investigated the bleeding tolerance and its determinants in anticoagulated patients with venous thromboembolism (VTE).

Methods: In 153 outpatients after VTE which occurred in the absence of any identifiable risk factor (aged 52 ± 15.7 years, 54.

Faster fibrin clot degradation characterizes patients with central pulmonary embolism at a low risk of recurrent peripheral embolism.

It is unclear whether thrombus location in pulmonary arteries is associated with particular clot characteristics. We assessed 156 patients following either central or peripheral pulmonary embolism (PE). Plasma clot lysis time, the rate of D-dimer release from plasma clots (D-D) with the maximum D-dimer concentration achieved (D-D), as well as fibrin formation on turbidimetry, plasma clot permeation, thrombin generation, and fibrinolytic parameters were measured 3-6 months after PE.