A Prospective, Randomized, Double-blind, Placebo-controlled Study of Orbital Radiotherapy for Graves' Ophthalmopathy.

Context: Although widely used for more than 85 years, the efficacy of radiotherapy for Graves' ophthalmopathy (GO) has not been established convincingly.

Objective: To evaluate the efficacy of radiotherapy for GO.

Design: Prospective, randomized, internally controlled, double-blind clinical trial in a tertiary care academic medical center.

The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study.

Background: To assess the risk of cerebrovascular accidents (CVAs) and second brain tumors (SBTs) in patients with pituitary adenoma after surgery or radiotherapy.

Methods: A cohort of 143 people from Olmsted County, who were diagnosed with pituitary adenoma between 1933 and 2000, was studied. Only patients from Olmsted County were included because of the unique nature of medical care in Olmsted County, which allows the ascertainment of virtually all cases of pituitary adenoma for this community's residents and comparisons to the general population in the county.

Factors associated with endocrine deficits after stereotactic radiosurgery of pituitary adenomas.

Objective: To analyze the factors associated with anterior pituitary deficits after pituitary adenoma stereotactic radiosurgery (SRS).

Methods: The tumor, pituitary stalk, and pituitary gland were segmented on the dose plans of 82 patients (secreting tumors, n = 53; nonsecreting tumors, n=29) for dose-volume analysis. No patient had undergone prior radiation therapy and all patients had at least 12 months of endocrinological follow-up (median, 63 months; mean, 69 months; range, 13-134).

Radiation complications and tumor control after 125I plaque brachytherapy for ocular melanoma.

Purpose: To determine the outcome of 125I plaque brachytherapy at our institution and identify the risk factors associated with the development of radiation complications, tumor recurrence, and metastasis.

Patients And Methods: From 1986 to 2000, 156 patients underwent 125I episcleral plaque (COMS design) application for the treatment of ocular melanoma. Chart analysis of follow-up ophthalmologic appointments assessed the incidence of ocular side effects after therapy.

Leksell Gamma Knife coordinate setting slippage: how often, how much?

Object: The aim of this study was to determine the incidence and magnitude of coordinate setting slippage during gamma knife surgery (GKS).

Methods: Thirty-six consecutive patients undergoing GKS with a Leksell unit between June and December 2000 had their coordinates (right and left x-, y-, and z-coordinates; 1548 coordinates; 258 isocenters) and gamma angles checked after the delivery of treatment to each isocenter to determine whether the coordinate settings had slipped and, if so, which settings and the magnitude of the slippage.

Conclusions: Coordinate setting slippage during GKS with a Leksell unit does occur but is rare.

Selective identification of different brachytherapy sources, ferromagnetic seeds, and fiducials in the prostate using an automated seed sorting algorithm.

Purpose: Routine permanent prostate brachytherapy (PPB) includes CT-based postimplant dosimetry (PID). A method of identifying different source types from CT data in the same implant volume is described.

Methods And Materials: A previously described automatic method for seed localization using CT data is used in this study.

Irradiation of the inguinal lymph nodes in patients of differing body habitus: a comparison of techniques and resulting normal tissue complication probabilities.

The treatment of the inguinal lymph nodes with radiotherapy is strongly influenced by the body habitus of the patient. The effect of 7 radiotherapy techniques on femoral head doses was studied. Three female patients of differing body habitus (ectomorph, mesomorph, endomorph) were selected.

Retinal microvascular abnormalities in patients treated with external radiation for graves ophthalmopathy.

Background: A prospective study was conducted to determine if external ionizing radiation could favorably influence the orbital manifestations of Graves ophthalmopathy. Diabetes and untreated systemic hypertension were exclusion criteria. Radiation was directed to the orbits of 42 affected patients using 0.

The aftermath of orbital radiotherapy for graves' ophthalmopathy.

Objective: To determine whether long-term improvement could be observed after orbital radiotherapy for Graves' disease; in addition, to evaluate ancillary treatments needed for those who have received radiotherapy, to search for late-emerging adverse consequences of radiotherapy, and to relate orbital changes to serum levels of thyroid-stimulating immunoglobulin (TSI).

Design: Three-year follow-up of noncomparative interventional case series.

Participants: Forty-two patients.

Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery.

Background: We evaluated toxicity and long-term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors.

Methods: Twenty-five consecutive patients (age, 30-88 years; 17 women, 8 men) who underwent stereotactic radiosurgery with the Leksell Gamma Knife (dose, 12-18 Gy) were prospectively followed. MRI and clinical examinations were performed at 6 months and 1, 2, and 3 years, and then every 2 years.