Novel Pyridinium Cross-Link Structures Derived from Glycolaldehyde and Glyoxal.

Short-chained α-hydroxycarbonyl compounds such as glycolaldehyde (GA) and its oxidized counterpart glyoxal (GX) are known as potent glycating agents. Here, a novel fluorescent lysine-lysine cross-link 1-(5-amino-5-carboxypentyl)-3-(5-amino-5-carboxy-pentylamino)pyridinium salt (-DLP) was synthesized and its structure unequivocally proven by H NMR, C-NMR attached proton test, and 2D NMR. Further characterization of chemical properties and mechanistic background was obtained in comparison to the known monovalent protein modification 2-ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine).

Speeding up the clinical routine: Compressed sensing for 2D imaging of lumbar spine disc herniation.

Purpose: Increasing economic pressure and patient demands for comfort require an ever-increasing acceleration of scan times without compromising diagnostic certainty. This study tested the new acceleration technique Compressed SENSE (CS-SENSE) as well as different reconstruction methods for the lumbar spine.

Methods: In this prospective study, 10 volunteers and 14 patients with lumbar disc herniation were scanned using a sagittal 2D T2 turbo spin echo (TSE) sequence applying different acceleration factors of SENSE and CS-SENSE.

Accelerated MRI of the knee. Quality and efficiency of compressed sensing.

Purpose: To evaluate potential clinical acceleration factors of Compressed SENSE (CS) in direct comparison with SENSE for fat saturated (fs), proton density-weighted (PD) 2D and 3D sequences of the knee.

Method: Twenty healthy volunteers were scanned with a 3 T scanner, all receiving a standard, fs 2D PD, three CS (CS 2, CS 3, CS 5) as well as time-equivalent SENSE accelerations (S 2, S 3, S 5). The fs 3D PD sequence was acquired with four CS (CS 6, CS 8, CS 10, CS 15) and equivalent SENSE (S 5.

Modification and Cross-Linking of Proteins by Glycolaldehyde and Glyoxal: A Model System.

Highly reactive intermediates of the Maillard reaction, such as glycolaldehyde and glyoxal, are precursors in the modification and cross-linking of proteins. Therefore, we investigated ribonuclease A modified by glycolaldehyde and glyoxal, separately. For the first time, various protein species derived by these aldehydes were successfully separated by ion-exchange chromatography and gel permeation chromatography.

Accelerated MRI of the Lumbar Spine Using Compressed Sensing: Quality and Efficiency.

Background: Decreasing MRI scan time is a key factor to increase patient comfort and compliance as well as the productivity of MRI scanners.

Purpose/hypothesis: Compressed sensing (CS) should significantly accelerate 3D scans. This study evaluated the clinical application and cost effectiveness of accelerated 3D T sequences of the lumbar spine.

Correction to: CT metal artifacts in patients with total hip replacements: for artifact reduction monoenergetic reconstructions and post-processing algorithms are both efficient but not similar.

The original version of this article, published on 03 May 2018, unfortunately contained a mistake. The following correction has therefore been made in the original.

CT metal artifacts in patients with total hip replacements: for artifact reduction monoenergetic reconstructions and post-processing algorithms are both efficient but not similar.

Objectives: This study compares metal artifact (MA) reduction in imaging of total hip replacements (THR) using virtual monoenergetic images (VMI), for MA-reduction-specialized reconstructions (MAR) and conventional CT images (CI) from detector-based dual-energy computed tomography (SDCT).

Methods: Twenty-seven SDCT-datasets of patients carrying THR were included. CI, MAR and VMI with different energy-levels (60-200 keV) were reconstructed from the same scans.

Metal artifact reduction by dual-layer computed tomography using virtual monoenergetic images.

Objective: The aim of the study was to investigate the performance and diagnostic value of metal artifact reduction in virtual monoenergetic images generated from dual-layer computed tomography (DLCT).

Methods: 35 patients that received a DLCT at the University Hospital Cologne and had an orthopedic implant in the examined region were included in this study. For each DLCT virtual monoenergetic images of different energy levels (64keV, 70keV, 105keV, 140keV, 200keV and an optimized photon energy) were reconstructed and analyzed by three blinded observers.