Publications by authors named "Robert Porrazzo"
Article Synopsis
- Tamoxifen is an effective breast cancer treatment but raises the risk of blood clots, with unknown effects of its plasma levels on coagulation.
- A study measured tamoxifen and its active form, endoxifen, in 141 patients after 3 and 6 months of treatment, analyzing their correlation with anticoagulant proteins and thrombin generation.
- The results showed that higher levels of tamoxifen and endoxifen were not linked to increased blood coagulation risk, indicating that increasing the dose may not further enhance clot risk.
Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs. However, the effects of this prolonged scalp cooling on the pharmacokinetics of chemotherapy have never been investigated. In this study, we compared the pharmacokinetics of the widely used chemotherapeutic agent paclitaxel (weekly dose of 80-100 mg/m) in female patients with solid tumors using concomitant scalp cooling ( = 14) or not ( = 24).
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