Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model?

Purpose: To determine whether arterial spin-labeling (ASL) magnetic resonance (MR) imaging findings at baseline and early during antiangiogenic therapy can predict later resistance to therapy.

Materials And Methods: Protocol was approved by an institutional animal care and use committee. Caki-1, A498, and 786-0 human renal cell carcinoma (RCC) xenografts were implanted in 39 nude mice.

An assessment of the sharpness of carotid artery tissue boundaries with acquisition voxel size and field strength.

A measure of the sharpness of vessel wall interfaces in carotid artery MRI may be useful for assessing the conspicuity of the wall's features. An edge detection technique was used to measure the signal intensity gradients in 2D time-of-flight (2D-TOF) and double-inversion recovery black-blood (DIR-BB) carotid artery images of normal subjects that were acquired at 1.5 T with 0.

3T MR of the prostate: reducing susceptibility gradients by inflating the endorectal coil with a barium sulfate suspension.

Most prostate MRI/MRS examinations are performed with an endorectal coil inflated with air, leading to an air-tissue interface that induces magnetic susceptibility gradients within the gland. Inflation of the coil with a barium sulfate suspension is described and compared to inflation with air or liquid perfluorocarbon (PFC). The B(0) field in the prostate gland was mapped for five healthy volunteers when the endorectal coil was inflated with each of the three agents.

Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity.

Objective: The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation.

Research Design And Methods: CBF was examined in 26 diabetic (aged 61.6 +/- 6.

Limits on activation-induced temperature and metabolic changes in the human primary visual cortex.

Changes in cerebral blood flow (CBF) and metabolism are now widely used to map and quantify neural activity, although the underlying mechanism for these changes is still incompletely understood. Magnetic resonance spectroscopy (MRS) at 3T, synchronized with a 32-s block design visual stimulation paradigm, was employed to investigate activation-induced changes in temperature and metabolism in the human primary visual cortex. A marginally significant increase in the local temperature of the visual cortex was found (0.

Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy.

Increased utilization of cross-sectional imaging has resulted in increased detection of incidental renal tumors. The noninvasive characterization of renal tissue has important implications for the diagnosis of renal malignancies and treatment monitoring. Recently, multiple breath-hold averaged proton magnetic resonance spectroscopy ((1)H-MRS) performed at high field has enabled the use of this noninvasive metabolic profiling technique for the investigation of the abdomen.

3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1).

Rationale And Objectives: High-resolution magnetic resonance imaging of the prostate at 1.5T has gained acceptance for pretherapeutic staging of prostate cancer. The aim of this study was to evaluate the potential clinical utility of combined pelvic phased-array and endorectal coils at 3T.