Publications by authors named "Robert Oldroyd"
Article Synopsis
- - The National Cancer Institute's CPTAC focuses on analyzing tumors using a proteogenomic approach, which combines genomic data with proteomic information to better understand cancer.
- - The consortium has developed a comprehensive dataset that includes genomic, transcriptomic, proteomic, and clinical data from over 1000 tumors across 10 different groups, aimed at enhancing cancer research.
- - The CPTAC team addresses challenges in integrating and analyzing multi-omics data, especially the complexities arising from combining nucleotide sequencing with mass spectrometry proteomics information.
Background: Adding docetaxel to androgen deprivation therapy (ADT) improves survival in patients with metastatic, hormone-sensitive prostate cancer, but uncertainty remains about who benefits most. We therefore aimed to obtain up-to-date estimates of the overall effects of docetaxel and to assess whether these effects varied according to prespecified characteristics of the patients or their tumours.
Methods: The STOPCAP M1 collaboration conducted a systematic review and meta-analysis of individual participant data.
Article Synopsis
- The study investigates how various histopathologic features, such as Gleason grade and maximum cancer core length (MCCL), affect the visibility of prostate cancer on MRI scans in men with elevated PSA levels and no prior biopsy.
- It analyzes data from the Prostate MRI Imaging Study (PROMIS), focusing on MRI results correlated to specific areas of the prostate known as Barzell zones, using expert review of imaging and pathology findings.
- Findings indicate that higher Gleason scores and longer cancer core lengths significantly increase the odds of MRI visibility, while factors like prostate volume and the presence of prostatic intraepithelial neoplasia (PIN) also play important roles.
Background: Clinical Trials Units are encouraged to integrate Patient and Public Involvement (PPI) into all aspects of trial design, running and oversight. This research explored the induction and training of PPI Contributors joining trial oversight committees and was used to update the Medical Research Council Clinical Trials Unit at University College London's (MRC CTU at UCL) induction pack for new PPI Contributors.
Methods: Published and unpublished materials provided by other CTUs and research organisations on training for PPI Contributors on oversight committees were reviewed, with themes then triangulated to identify the most common topics covered in induction training.
Gleason score 7 prostate cancer with a higher proportion of pattern 4 (G4) has been linked to genomic heterogeneity and poorer patient outcome. The current assessment of G4 proportion uses estimation by a pathologist, with a higher proportion of G4 more likely to trigger additional imaging and treatment over active surveillance. This estimation method has been shown to have inter-observer variability.
View Article and Find Full Text PDFBackground: False positive multiparametric magnetic resonance imaging (mpMRI) phenotypes prompt unnecessary biopsies. The Prostate MRI Imaging Study (PROMIS) provides a unique opportunity to explore such phenotypes in biopsy-naïve men with raised prostate-specific antigen (PSA) and suspected cancer.
Objective: To compare mpMRI lesions in men with/without significant cancer on transperineal mapping biopsy (TPM).
Background: All risk stratification strategies in cancer overlook a spectrum of disease. The Prostate MR Imaging Study (PROMIS) provides a unique opportunity to explore cancers that are overlooked by multiparametric magnetic resonance imaging (mpMRI).
Objective: To summarise attributes of cancers that are systematically overlooked by mpMRI.
Background: Men with suspected prostate cancer usually undergo transrectal ultrasound (TRUS)-guided prostate biopsy. TRUS-guided biopsy can cause side effects and has relatively poor diagnostic accuracy. Multiparametric magnetic resonance imaging (mpMRI) used as a triage test might allow men to avoid unnecessary TRUS-guided biopsy and improve diagnostic accuracy.
View Article and Find Full Text PDFBackground: Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy.
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