Publications by authors named "Robert Muffaletto"
Article Synopsis
- NG2 is a unique protein in the spinal cord that both hinders nerve growth after injury and blocks nerve signal transmission, while also possibly aiding in forming synapses.
- Researchers hypothesized that neutralizing NG2's inhibitory roles without removing it entirely could improve recovery after spinal cord injuries, leading to the development of a gene therapy (AAV-NG2Ab) that produces antibodies against NG2.
- In experiments on injured rats, treatment with AAV-NG2Ab, especially when combined with neurotrophin NT-3, resulted in notable improvements in nerve transmission, movement, and bladder control compared to control groups, highlighting its potential in enhancing recovery post-injury.
