Access to Heterobimetallic M/Cu Complexes with a Multichelate Platform and Their Reactivity Studies in CO2RR.

We describe the selective formation of heterobimetallic complexes, exploiting the coordination trends of the developed bis-terpyridyl -1,2-cyclohexadiamine platform (). Following a stepwise addition, we first reacted ligand toward tetrakisacetonitrile transition metal precursors, [M(MeCN)][BF] (where M = Fe or Ni), to generate the monometallic complexes ([FeL][BF]) and ([NiL][BF]). These species were later combined with the tetrakisacetonitrile precursor [Cu(MeCN)][BF], generating the corresponding heterobimetallic complexes ([FeCuL(MeCN)][BF]) and ([NiCuL(MeCN)][BF]).

How will the cumulative effects of fishing and climate change affect the health and resilience of the Celtic Sea ecosystem?

Ecosystems are subject to increasing anthropogenic pressures worldwide. Assessing cumulative effects of multiple pressures and their impacts on recovery processes is a daunting scientific and technical challenge due to systems' complexity. However, this is of paramount importance in the context of ecosystem-based management of natural systems.

Tear Protein Biomarkers for Ocular Mucous Membrane Pemphigoid Uncovered Using Targeted LC-MS/MS.

Mucous membrane pemphigoid (MMP) is a multisystemic rare autoimmune disease affecting the skin and mucous membranes. Ocular involvement is characterized by chronic conjunctival inflammation causing scar formation, leading to corneal opacification and vision loss. Conjunctival biopsies are currently used to confirm diagnosis, and the associated immunosuppression treatments prescribed can have serious consequences on patients.

[Artificial intelligence in healthcare: A survival guide for internists].

Artificial intelligence (AI) is experiencing considerable growth in medicine, driven by the explosion of available biomedical data and the emergence of new algorithmic architectures. Applications are rapidly multiplying, from diagnostic assistance to disease progression prediction, paving the way for more personalized medicine. The recent advent of large language models, such as ChatGPT, has particularly interested the medical community, thanks to their ease of use, but also raised questions about their reliability in medical contexts.

Chiasmal Decussation in Oculo-Cutaneous Albinism Type 8.

Purpose: Albinism is a genetic disorder characterized by a defect in melanin biosynthesis. Ophthalmological and dermatological impairments vary according to the patient genotype and are highly heterogenous. Recently, variants in the DCT gene were showed to be responsible for a new type of oculocutaneous albinism (OCA) named OCA8.

Development of Bio-Composites from Milkweed Fibers Using Air-Laid Spike Process for Automobile Dashboard Applications.

This study focused on examining the reinforcement of milkweed fibers in polylactic acid (PLA) bio-composites used for dashboards in car interiors. Milkweed fiber is a natural fiber with a hollow structure that provides tremendous thermal insulation and noise resistance properties. Firstly, the milkweed fibers were blended with PLA fibers in a weight ratio of 75:25 using an air-laying process.

Association between parity and gravidity & hypertension and blood pressure: protocol for a systematic review and meta-analysis.

Introduction: Cardiovascular disease is the leading cause of death among women worldwide, and hypertension is one of the most prevalent and modifiable risk factors. Parity and gravidity, independent of pregnancy complications, have each been associated with hypertension, although results are conflicting. Therefore, we propose to estimate the association between parity and gravidity with hypertension and blood pressure in a systematic review of the literature.

Beyond the Microbiome: The Role of the Metabolome and Diet in Antitumor Immunity.

Microbiome-derived or -modulated metabolites (short-chain fatty acids, bile acids, and amino acids) could mediate antitumor immunity. Diet offers an actionable route for manipulating both the microbiome and the metabolome. Diet- and microbiome-directed trials with robust translational correlates are eagerly awaited.

Neurological manifestations in patients with VEXAS syndrome.

Background: VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a recently described syndrome linked to somatic mutations in the UBA1 gene, causing systemic autoinflammatory manifestations. To date, few data are available concerning neurological manifestations. The aim of this study was to describe their prevalence, clinical spectrum and outcome under treatment.

Management and outcome of mesh infection after abdominal wall reconstruction in a tertiary care center.

Purpose: Abdominal wall reconstruction is a common surgical procedure, with a post-operative risk of mesh-associated infection of which management is poorly known. This study aims to comprehensively analyze clinical and microbiological aspects of mesh infection, treatment modalities, and associated outcomes.

Methods: Patients with abdominal mesh infection were included in a retrospective observational cohort (2010-2023).

Bridging Needs and Expectations of Individuals With Physical Disabilities and Community Services Stakeholders for the Cocreation of an Adapted Physical Activity Platform in Virtual Reality: Qualitative Study.

Background: Physical activity supports the health and well-being of individuals with physical disabilities. Despite the significance of engaging in physical activity, barriers faced by individuals with disabilities, such as limited access to adapted facilities and lack of transportation, can restrict their participation. Community organizations play a role in addressing these challenges, but virtual reality (VR) also offers a way to diversify adapted activities.

Position statement and guidelines about Endoscopic Sleeve Gastroplasty (ESG) also known as "Endo-sleeve".

IS ESG EFFECTIVE IN THE TREATMENT OF OBESITY AND ASSOCIATEDCOMORBIDITIES?: Endoscopic Sleeve Gastroplasty (ESG) is more effective than lifestyle modifications alone for weight loss and improving obesity-related comorbidities. While it has less effect on weight loss compared to Laparoscopic Sleeve Gastrectomy (LSG) in the short to medium term, it offers similar comorbidities resolution to LSG. IS ESG A SAFE PROCEDURE, AND WHAT ARE ITS RISKS?: The safety profile of ESG is consistently supported in the literature.

Spontaneous rupture of aortic aneurysm due to Listeria monocytogenes in an immunocompetent patient and review of the literature.

Infectious aneurysms represent <5 % of cases [1] with a crucial and challenging diagnosis. Staphylococcus, Streptococcus, Enterobacteria are mostly involved but unusual pathogens like Listeria monocytogenes can be responsible. Collecting data of these rare situations allows to improve diagnosis.

The evolving role of liver biopsy: Current applications and future prospects.

Histopathologic evaluation of liver biopsy has played a longstanding role in the diagnosis and management of liver disease. However, the utility of liver biopsy has been questioned by some, given the improved imaging modalities, increased availability of noninvasive serologic tests, and development of artificial intelligence over the past several years. In this review, we discuss the current and future role of liver biopsy in both non-neoplastic and neoplastic liver diseases in the era of improved noninvasive laboratory, radiologic, and digital technologies.

Hybrid CIGS-Cobalt Quaterpyridine Photocathode with Backside Illumination: A New Paradigm for Solar Fuel Production.

Chalcogenide-based thin-film solar cell optimized for rear illumination and used for CO reduction is presented. Central to this innovation is a thinner, Cu(In,Ga)S chalcopyrite absorber coated with a robust metallic top layer, which potentially surpasses the performance of conventional front-illuminated designs. Using cobalt quaterpyridine molecular catalyst, photocurrent densities for CO reduction exceeding 10 mA/cm at 0.

Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Bridge to Bariatric Surgery in Morbidly Obese Patients with Cirrhosis and Clinically Significant Portal Hypertension.

Background: In cirrhotic patients, portal hypertension increases mortality after surgery. We evaluated the impact of pre-operative transjugular intrahepatic portosystemic shunt (TIPS) on the outcomes of bariatric surgery in cirrhosis.

Methods: Multicentric retrospective cohort.

Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak.

Aim: The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023.

Methods: Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics).

Fumagillin Shortage: How to Treat Microsporidiosis in Solid Organ Transplant Recipients in 2024?

Unlabelled: Intestinal microsporidiosis caused by is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication.

Cortical hemodynamics of electrographic status epilepticus in the critically ill.

Objectives: The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near-infrared spectroscopy (fNIRS) combined with video-electroencephalography (vEEG) to monitor brain hemodynamics continuously and non-invasively in critically ill adult patients experiencing electrographic SE. Our primary focus is to investigate neurovascular coupling and cerebrovascular changes associated with seizures, particularly during recurring and/or prolonged episodes.

Ciprofloxacin-susceptible but levofloxacin-resistant Pseudomonas aeruginosa clinical strains with Vitek2: which mechanism involved and consequences in case of fluoroquinolone treatment?

Purpose: Pseudomonas aeruginosa clinical strains isolated harbored sometimes an atypical phenotype using the automated Vitek2: ciprofloxacin-susceptibility but levofloxacin-resistance according to 2019 CA-SFM criteria. The aims of this study are to investigate the resistance mechanism(s) involved and to identify the consequences on fluoroquinolone treatment.

Methods: Strain resistance profile, patient's data were recovered and reviewed from the database.

Clinical application and prognostic value of computed tomography examination in foals diagnosed with osteomyelitis: Forty-four cases.

Computed tomography (CT) is increasingly recognized as superior to conventional imaging methods for diagnosing osteomyelitis in foals. However, comprehensive studies in this area are limited. This study aims to report on clinical cases of osteomyelitis in foals, establishing a relationship between CT findings and survival outcomes.

Incidental finding of a pathogenic mosaicism in the NF1 gene detected by near infrared fundus imaging - a case report.

Background: Neurofibromatosis type 1 is an autosomal dominant disorder predisposing to numerous tumors. Sporadic mutations account for half of the cases. They can occur on a mosaic pattern, which might remain undiagnosed, depending on the clinical phenotype.