Rapid Aminations of Functionalized Aryl Fluorosulfates in Water.

Aryl fluorosulfates of varying complexities have been used in amination reactions in water using a new Pd oxidative addition complex (OAC-1) developed specifically to match the needs of the fine chemicals industry, not only in terms of functional group tolerance, but also reflecting time considerations associated with these important C-N couplings. Also especially noteworthy is that they replace both PFAS-related triflates and nonaflates, which are today out of favor due to recent government regulations. The new complex based on the BippyPhos ligand is used at low loadings and under aqueous micellar conditions.

Ligated Pd-Catalyzed Aminations of Aryl/Heteroaryl Halides with Amines under Sustainable Aqueous Micellar Conditions.

Sustainable technology for constructing Pd-catalyzed C-N bonds involving aliphatic amines is reported. A catalytic system that relies on , a known and , and a are combined, leading to a newly developed procedure. This new technology can be used in ocean water with equal effectiveness.