Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding.

Aim: Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing - including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury.

Materials & Methods: The effects of Cx43 CT peptide were studied in mouse and pig models of cutaneous injury.