Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus.

This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for between a common automated system (Vitek 2) and the E-test method in patients with bloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg∙h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data ( < 0.0001).

Streptococcus pneumoniae serotypes: nine-year experience at a level-one trauma center.

Streptococcus pneumoniae isolates from adults hospitalized with invasive pneumococcal disease (IPD) were collected at Regions Hospital in St. Paul from 2002 through 2010. Of 200 sequential, nonduplicative isolates collected and serotyped, serotypes 3, 7F and 19A were found to be the most common.