VizCommender: Computing Text-Based Similarity in Visualization Repositories for Content-Based Recommendations.

Cloud-based visualization services have made visual analytics accessible to a much wider audience than ever before. Systems such as Tableau have started to amass increasingly large repositories of analytical knowledge in the form of interactive visualization workbooks. When shared, these collections can form a visual analytic knowledge base.

SignalLens: Focus+Context applied to electronic time series.

Electronic test and measurement systems are becoming increasingly sophisticated in order to match the increased complexity and ultra-high speed of the devices under test. A key feature in many such instruments is a vastly increased capacity for storage of digital signals. Storage of 10(9) time points or more is now possible.

DNA-based fish species identification protocol.

We have developed a fast, simple, and accurate DNA-based screening method to identify the fish species present in fresh and processed seafood samples. This versatile method employs PCR amplification of genomic DNA extracted from fish samples, followed by restriction fragment length polymorphism (RFLP) analysis to generate fragment patterns that can be resolved on the Agilent 2100 Bioanalyzer and matched to the correct species using RFLP pattern matching software. The fish identification method uses a simple, reliable, spin column- based protocol to isolate DNA from fish samples.

Cerebral: visualizing multiple experimental conditions on a graph with biological context.

Systems biologists use interaction graphs to model the behavior of biological systems at the molecular level. In an iterative process, such biologists observe the reactions of living cells under various experimental conditions, view the results in the context of the interaction graph, and then propose changes to the graph model. These graphs ser ve as a form of dynamic knowledge representation of the biological system being studied and evolve as new insight is gained from the experimental data.

VistaClara: an expression browser plug-in for Cytoscape.

Summary: VistaClara is a plug-in for Cytoscape which provides a more flexible means to visualize gene and protein expression within a network context. An extended attribute browser is provided in the form of a graphical and interactive permutation matrix that resembles the heat map displays popular in gene-expression analysis. This extended browser permits a variety of display options and interactions not currently available in Cytoscape.

PROCAM Study: risk prediction for myocardial infarction using microfluidic high-density lipoprotein (HDL) subfractionation is independent of HDL cholesterol.

Background: High-density lipoprotein (HDL) subfractions are among the new emerging risk factors for atherosclerosis. In particular, HDL 2b has been shown to be linked to cardiovascular risk. This study uses a novel microfluidics-based method to establish HDL 2b clinical utility using samples from the Prospective Cardiovascular Muenster (PROCAM) Study.

Overview use in multiple visual information resolution interfaces.

In interfaces that provide multiple visual information resolutions (VIR), low-VIR overviews typically sacrifice visual details for display capacity, with the assumption that users can select regions of interest to examine at higher VIRs. Designers can create low-VIRs based on multi-level structure inherent in the data, but have little guidance with single-level data. To better guide design tradeoff between display capacity and visual target perceivability, we looked at overview use in two multiple-VIR interfaces with high-VIR displays either embedded within, or separate from, the overviews.

Differences in vascular bed disease susceptibility reflect differences in gene expression response to atherogenic stimuli.

Atherosclerosis occurs predominantly in arteries and only rarely in veins. The goal of this study was to test whether differences in the molecular responses of venous and arterial endothelial cells (ECs) to atherosclerotic stimuli might contribute to vascular bed differences in susceptibility to atherosclerosis. We compared gene expression profiles of primary cultured ECs from human saphenous vein (SVEC) and coronary artery (CAEC) exposed to atherogenic stimuli.

Pathway analysis of coronary atherosclerosis.

Large-scale gene expression studies provide significant insight into genes differentially regulated in disease processes such as cancer. However, these investigations offer limited understanding of multisystem, multicellular diseases such as atherosclerosis. A systems biology approach that accounts for gene interactions, incorporates nontranscriptionally regulated genes, and integrates prior knowledge offers many advantages.

An architecture for biological information extraction and representation.

Motivations: Technological advances in biomedical research are generating a plethora of heterogeneous data at a high rate. There is a critical need for extraction, integration and management tools for information discovery and synthesis from these heterogeneous data.

Results: In this paper, we present a general architecture, called ALFA, for information extraction and representation from diverse biological data.

Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA.

Array-based comparative genomic hybridization (CGH) measures copy-number variations at multiple loci simultaneously, providing an important tool for studying cancer and developmental disorders and for developing diagnostic and therapeutic targets. Arrays for CGH based on PCR products representing assemblies of BAC or cDNA clones typically require maintenance, propagation, replication, and verification of large clone sets. Furthermore, it is difficult to control the specificity of the hybridization to the complex sequences that are present in each feature of such arrays.