We investigated whether hypothermia and hyperthermia can alter the efficacy and potency of histamine at increasing the force of cardiac contractions in mice that overexpress the human H receptor only in their cardiac myocytes (labelled H-TG). Contractile studies were performed in an organ bath on isolated, electrically driven (1 Hz) left atrial preparations and spontaneously beating right atrial preparations from H-TG mice and wild-type (WT) littermate control mice. The basal beating rate in the right atrial preparations from H-TG mice was lowered by hypothermia (23 °C) and elevated by hyperthermia (42 °C).
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