Publications by authors named "Robert J Pengelly"
Article Synopsis
- Tumor-associated peptide-human leukocyte antigen complexes (pHLAs) are key targets for cancer therapies due to their role as cancer-specific epitopes on cell surfaces.
- Two strategies are being developed to redirect T cells against these targets: using affinity-enhanced T cell receptors (ImmTACs) and TCR-mimic antibodies.
- Research indicates that ImmTAC molecules have better selectivity and less off-target activity compared to TCR-mimic antibodies, which tend to bind more broadly, highlighting the importance of understanding pHLA specificity in designing effective cancer treatments.
Glycoside hydrolases (GHs) have attracted considerable attention as targets for therapeutic agents, and thus mechanism-based inhibitors are of great interest. We report the first structural analysis of a carbocyclic mechanism-based GH inactivator, the results of which show that the two Michaelis complexes are in H conformations. We also report the synthesis and reactivity of a fluorinated analogue and the structure of its covalently linked intermediate (flattened H half-chair).
View Article and Find Full Text PDFBacteria often produce toxins which kill competing bacteria. Colicins, produced by and toxic to Escherichia coli bacteria are three-domain proteins so efficient that one molecule can kill a cell. The C-terminal domain carries the lethal activity and the central domain is required for surface receptor binding.
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