Validation of predictive equations for resting energy expenditure in adult outpatients and inpatients.

Background & Aims: When individual energy requirements of adult patients cannot be measured by indirect calorimetry, they have to be predicted with an equation. The aim of this study was to analyze which resting energy expenditure (REE) predictive equation was the best alternative to indirect calorimetry in adult patients.

Methods: Predictive equations were included when based on weight, height, gender and/or age.

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.

Background: The objective is to study the population pharmacokinetics of lorazepam and midazolam in critically ill patients with acute renal failure who are treated with continuous venovenous hemofiltration (CVVH).

Methods: Twenty critically ill patients with acute renal failure on CVVH therapy were administered either lorazepam (n = 10) or midazolam (n = 10) by continuous infusion. CVVH was performed with an ultrafiltrate flow of 2 L/h with filtrate substitution in the predilution or postdilution mode.