Publications by authors named "Robert J Beal"
Aims: Macrophages play an essential role in cancer development. Tumor-associated macrophages (TAMs) have predominantly M2-like attributes that are associated with tumor progression and poor patient survival. Numerous methods have been reported for differentiating and polarizing macrophages in vitro, but there is no standardized and validated model for creating TAMs.
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- Rising obesity rates are linked to an increase in early-onset colorectal cancer, with specific cytokine expressions impacting patient survival.
- Researchers examined how the obesity hormone leptin and the macrophage metabolite itaconate affect important cellular mechanisms related to this cancer type.
- Results showed that itaconate significantly downregulated peroxisome proliferator activated receptor gamma while elevating anti-inflammatory cytokines, suggesting it might play a crucial role in linking obesity to early-onset colorectal cancer.