Publications by authors named "Robert J Allsopp"
Article Synopsis
- Traumatic brain injury (TBI) affects many individuals, especially veterans and athletes, and has serious, long-term consequences for brain health.
- Current research explores the role of fibroblast growth factor (FGF) proteins in protecting cells, highlighting knowledge gaps regarding how heparin and similar molecules activate bFGF and how mutations affect its stability.
- Using temperature replica exchange, the study identified a new binding site on bFGF and revealed that various sugars affect bFGF interactions similarly to heparin, underscoring the need for a deeper understanding of TBI mechanisms for better treatment development.
All-atom molecular dynamics simulations are used with the highly mobile membrane mimetic method to study the α-α peptide of the critical yeast Osh4 peripheral membrane protein. This research focuses on the impact of 1-palmitoyl-2-oleoyl--glycero-phosphatidylinoside 4,5-bisphosphate (PIP2) lipids and 1-palmitoyl-2-oleoyl--glycero-3-phospho-l-serine on the protein's ability to bind to the membrane. Details of the binding mechanism are described qualitatively and quantitatively by measuring the position of the deepest residues, angle of the peptide during binding, root mean square deviation of the atomic positions within the peptide, and interaction energy, while changing variables, such as the force field used and the presence of the PIP2 lipids.
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