Publications by authors named "Robert Hedley"
Objectives: Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aims to characterise the cellular composition of advanced OA synovium and to explore potential correlations between different cell types and patient demographics or clinical scores.
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- - Recent research indicates that inflammation plays a crucial role in the development and worsening of tendon diseases, particularly in the Achilles tendon, which has not been as thoroughly studied as the rotator cuff tendons.
- - Biopsies from patients with Achilles tendinopathy or rupture showed high levels of inflammation markers, including specific immune cells (CD14+ and CD68+), and activation of inflammatory pathways, suggesting chronic inflammation in these conditions.
- - Findings imply that both acute inflammation and chronic inflammatory responses are involved in Achilles tendon injuries, and targeting chronic inflammation could offer new treatment options.
Background: Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood.
Methods: We investigated stromal fibroblast activation signatures in tissues and cells from patients with tendinopathy.
Many eastern European countries are expanding primary care. Experience in Kosovo shows how some of the difficulties can be overcome
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