Publications by authors named "Robert Harle"
Background: Photoplethysmography (PPG) sensors, typically found in wrist-worn devices, can continuously monitor heart rate (HR) in large populations in real-world settings. Resting heart rate (RHR) is an important biomarker of morbidities and mortality, but no universally accepted definition nor measurement criteria exist. In this study, we provide a working definition of RHR and describe a method for accurate measurement of this biomarker, recorded using PPG derived from wristband measurement across the 24-hour cycle.
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- The study assessed the clinical utility of IgA antibodies in patients with antiphospholipid syndrome (APS), particularly focusing on IgA aβ2GPI antibodies.
- The analysis of 439 patients revealed a significant presence of aβ2GPI IgA antibodies (16% in patients vs. 1% in controls), which were linked to thrombosis and systemic lupus erythematosus (SLE).
- Findings suggest the identification of specific target domains in aβ2GPI IgA could help evaluate thrombotic risk in SLE patients, highlighting the potential importance of these antibodies in clinical settings.