Publications by authors named "Robert Handreka"
Article Synopsis
- - Autoantibodies against Caspr2 are linked to limbic autoimmune encephalitis and pain, with 36% of patients in a study experiencing pain, which is often severe and sometimes the main symptom.
- - Two main pain phenotypes were identified: distal-symmetric burning pain and widespread pain with myalgia/cramps, highlighting variability among patients.
- - There is a correlation between anti-Caspr2 autoantibodies and pre-existing chronic pain risk factors, suggesting that these autoantibodies could indicate decreased pain sensitivity, warranting testing in patients with different types of pain.
Seizure Semiology in Antibody-Associated Autoimmune Encephalitis.
Neurol Neuroimmunol Neuroinflamm
November 2022
Article Synopsis
- - The study evaluates seizure characteristics in patients with antibody-associated autoimmune encephalitis (ab + AE) focusing on the three most common antibodies: NMDAR, LGI1, and GAD, involving 320 patients across multiple centers in Germany.
- - Seizures were prevalent in these patients, with frequencies of 60% in NMDAR+, 78% in LGI1+, and 65% in GAD+, and certain types of seizures such as faciobrachial dystonic seizures and status epilepticus presented uniquely or more frequently in specific antibody groups.
- - The findings suggest that seizure types can help in diagnosis, with distinct patterns observed among different antibodies, indicating that NMDAR+ patients tend to have
Autoimmune encephalitis (AE) can rarely manifest as a predominantly psychiatric syndrome without overt neurological symptoms. This study's aim was to characterize psychiatric patients with AE; therefore, anonymized data on patients with suspected AE with predominantly or isolated psychiatric syndromes were retrospectively collected. Patients with readily detectable neurological symptoms suggestive of AE (e.
View Article and Find Full Text PDFGenome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis.
Neurol Neuroimmunol Neuroinflamm
November 2021
Article Synopsis
- The study investigates the genetic factors involved in anti-NMDA receptor (anti-NMDAR) encephalitis, a common autoimmune brain disease.
- Researchers conducted a genome-wide association study with 178 patients and 590 healthy individuals, identifying significant genetic variants on chromosomes 15 and 11.
- The findings indicate potential causal genes linked to immune function and inflammation, suggesting further research could uncover more genetic influences and clarify the disease's mechanisms.
Introduction: In acute optic neuritis, high dose steroid therapy as first - line treatment is contraindicated in early pregnancy, therapeutic plasma exchanges (TPE) represent an alternative. We report a case of a pregnant woman with progressive, acute optic neuritis subjected to membrane-based therapeutic plasma exchange with extracorporal citrate-based anticoagulation.
Case Presentation: A 35 year-old second-time pregnant woman (4th week of gravidity) of Caucasian ethnicity complained of visual impairment of the right eye.
Anaplastic lymphoma kinase inhibitor-associated myositis.
Neurol Neuroimmunol Neuroinflamm
July 2020
We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10 , OR = 13.
View Article and Find Full Text PDF