Heritability of performance deficit accumulation during acute sleep deprivation in twins.

Study Objectives: To determine if the large and highly reproducible interindividual differences in rates of performance deficit accumulation during sleep deprivation, as determined by the number of lapses on a sustained reaction time test, the Psychomotor Vigilance Task (PVT), arise from a heritable trait.

Design: Prospective, observational cohort study.

Setting: Academic medical center.

Noninferiority of functional outcome in ambulatory management of obstructive sleep apnea.

Rationale: Home portable monitor testing is increasingly being used to diagnose patients with obstructive sleep apnea (OSA) and to initiate them on continuous positive airway pressure (CPAP) treatment.

Objectives: To compare functional outcome and treatment adherence in patients who receive ambulatory versus in-laboratory testing for OSA.

Methods: Veterans with suspected OSA were randomized to either home testing or standard in-laboratory testing.

Family aggregation of upper airway soft tissue structures in normal subjects and patients with sleep apnea.

Rationale: Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation.

Objectives: We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea.

Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging.

We used sophisticated volumetric analysis techniques with magnetic resonance imaging in a case-control design to study the upper airway soft tissue structures in 48 control subjects (apnea-hypopnea index, 2.0 +/- 1.6 events/hour) and 48 patients with sleep apnea (apnea-hypopnea index, 43.