Publications by authors named "Robert Flintham"
Article Synopsis
- - This study aims to determine the safe planning margins (PRV) for protecting optic nerves during CyberKnife stereotactic radiosurgery (SRS) due to potential motion of the nerves during treatment.
- - MRI scans of healthy volunteers were used to assess optic nerve motion in various directions, leading to the calculation of two different PRV margins: a non-isotropic margin of 3mm in the left/right direction and an isotropic margin of 1mm when patients maintain a neutral gaze.
- - The findings suggest that incorporating these PRV margins in CyberKnife treatment plans is crucial to minimize risks to the optic nerves, particularly in patients with perioptic lesions like sphenoid wing meningiomas.
Introduction: Functional magnetic resonance imaging (fMRI) can be used to assess language and memory function as part of pre-surgical decision making in refractory epilepsy. Although language paradigms are well established, memory paradigms are not widely used in clinical practice due to a lack of evidence for robust and reliable methods. Here, we aim to investigate the clinical utility of the Home Town Walk (HTW) paradigm for personalized treatment decisions in medial temporal lobe epilepsy.
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- A diagnostic delay in identifying primary central nervous system lymphoma (PCNSL) often arises from recognizing lesions incorrectly and premature steroid treatment, complicating biopsy results.
- Multiparametric MRI, which includes advanced imaging techniques, is emphasized as crucial for reducing diagnostic uncertainties in PCNSL cases.
- In a study of 10 patients, most exhibited consistent MRI parameters indicative of PCNSL, suggesting this imaging approach could streamline diagnosis and hasten treatment initiation.
Article Synopsis
- MRI is crucial for evaluating brain lesions, but conventional MRI lacks specificity.
- Multiparametric MRI, which includes advanced techniques like diffusion and perfusion-weighted imaging, offers better insights into tissue conditions.
- This review aims to illustrate the effectiveness of multiparametric MRI in diagnosing and planning treatment, showcasing cases that highlight its superior ability to distinguish between cancerous and non-cancerous lesions compared to standard MRI.
Background: Chronic hepatitis C (CHC) is associated with systemic insulin resistance, yet there are limited data on the tissue-specific contribution in vivo to this adverse metabolic phenotype, and the effect of HCV cure.
Methods: We examined tissue-specific insulin sensitivity in a cohort study involving 13 patients with CHC compared to 12 BMI-matched healthy control subjects. All subjects underwent a two-step clamp incorporating the use of stable isotopes to measure carbohydrate and lipid flux (hepatic and global insulin sensitivity) with concomitant subcutaneous adipose tissue microdialysis and biopsy (subcutaneous adipose tissue insulin sensitivity).
Context: 5α-Reductase 1 and 2 (SRD5A1, SRD5A2) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of DHT. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and finasteride (selective SRD5A2 inhibitor) are commonly prescribed, but their potential metabolic effects have only recently been identified.
Objective: Our objective was to provide a detailed assessment of the metabolic effects of SRD5A inhibition and in particular the impact on hepatic lipid metabolism.