Publications by authors named "Robert F O'dea"
Background: The distinct absorption characteristics of the conventional enteric-coated, delayed-release (DR) and the novel extended-release (ER) divalproex sodium formulations are not well recognized.
Objective: To quantitatively and qualitatively differentiate the absorption characteristics of divalproex-DR and -ER formulations.
Methods: Healthy volunteers (N = 28) received single 1000 mg doses of divalproex-DR and divalproex-ER tablets in a crossover fashion.
Article Synopsis
- CYP3A5 genetic polymorphisms were studied to assess their impact on drug levels of ABT-773, a ketolide antibiotic, which is metabolized by both CYP3A5 and P-glycoprotein.
- Healthy volunteers with different CYP3A5 genotypes received various doses of ABT-773, and their drug levels were measured to explore the correlation with their genetic makeup.
- Results indicated that CYP3A5-negative individuals had significantly higher drug levels (AUC and Cmax) than CYP3A5-positive individuals, suggesting that genetic variants in CYP3A5 can influence the pharmacokinetics of ABT-773.