Publications by authors named "Robert F Lams"
Article Synopsis
- Malignant cells grow not just from their own factors, but also from the environment around them, especially cells like monocytes and macrophages.
- In acute myeloid leukemia, certain macrophages help the cancer grow instead of fighting it, and their presence in the body is linked to how long mice survive in experiments.
- A specific protein called Growth factor independence 1 is important because it affects how these macrophages change; without it, they are less likely to support the cancer.
Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant disease of the bone marrow. A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans. However, how GFI1(36N) predisposes to AML is poorly understood.
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