UV-VIS spectra as potential process analytical technology (PAT) for measuring the density of compressed materials: Evaluation of the CIELAB color space.

Measurement methods for determining the density of compressed materials, being a critical quality attribute, provide an important parameter for successful processing. In this study, a novel approach was developed for determining the density of compacts using ultraviolet-visible spectrophotometry. The assumption within this context was that a change in density affects the corresponding color information of the compact.

Novel ultrasonic in-die measurements during powder compression at production relevant speed.

A novel ultrasonic instrumentation was successfully implemented in a compaction simulator. A through-transmission set-up was realised with longitudinal and transverse transducers being alternately positioned inside Euro-D-modified punches. Key features of the data acquisition are described.

Pneumatic dry granulation: potential to improve roller compaction technology in drug manufacture.

Introduction: Solid dosage form manufacture still remains the most common in the production of pharmaceutical products. Established granulation processes can benefit from novel technical improvements, which can in turn enhance the behavior and properties of the process intermediates, that is, granules. These improvements in the manufacturing process can ultimately shorten development times, provide processing solutions for challenging materials and improve quality of drug delivery systems.