Healthcare costs and quality of life associated with the long-term outcome of anxiety disorders.

Background And Objectives: Anxiety disorders are costly; however, the relationship with treatment outcome has been neglected. This study examined healthcare costs and quality of life by diagnostic status (treatment outcome and the presence of comorbidity) at long-term follow-up.

Design And Methods: This cohort study comprized 317 patients entering treatment for at least one Axis I anxiety disorder.

Active glucagon-like peptide 1 quantitation in human plasma: a comparison of multiple ligand binding assay platforms.

There are a wide variety of ligand binding assay platforms available for implementation in present day bioanalytical laboratories. Selecting the platform that best suits a particular project's needs is highly dependent upon multiple assay characteristics. The active form of glucagon-like protein (GLP-1) is a biomarker of interest for type 2 diabetes (T2DM), and therefore a common target for quantitation.

Lessons learned from a study of a complementary therapy for self-managing hypertension and stress in women.

This report evaluates a Hawaiian-based, self-management intervention for reducing blood pressure (BP) and stress in women. It highlights lessons learned when using nonpharmacologic, complementary and alternative medicine (CAM) therapies. Specific participant characteristics and preferences should be considered for optimizing health outcomes in CAM research in nursing practice.

Long-term outcome of eight clinical trials of CBT for anxiety disorders: symptom profile of sustained recovery and treatment-resistant groups.

Background: Few clinical trials of cognitive behaviour therapy (CBT) for anxiety disorders have conducted follow-up beyond one year post-treatment. This paper summarises the long-term outcome of eight clinical trials of CBT for anxiety disorders in terms of diagnostic status, healthcare usage and symptom severity and compares the symptom profile of participants with the best and worst outcomes relative to chronic depression and the normal population.

Methods: Follow-up at 2-14years with 396 patients (51% of those available to contact) employed structured diagnostic interview, assessment of healthcare usage and self-report measures of symptom severity.

Modification of amyloid-beta(1-40) by a protease inhibitor creates risk of error in mass spectrometric quantitation of amyloid-beta(1-42).

Matrix-assisted laser desorption mass spectrometry successfully analyzes mixed populations of amyloid-beta (Abeta) peptides, providing a profile in which changes caused by drug action are directly observed. A spectrum of Abeta immunocaptured from guinea pig brain included a novel component with monoisotopic [M+H]+ at 4511.22, close to the monoisotopic value of [M+H]+ for Abeta(1-42) of 4512.

Developmental experiences of child sexual abusers and rapists.

Objective: The aim of this study is to identify the distinct developmental experiences associated with child sexual abuse and rape.

Method: For 269 sexual offenders (137 rapists and 132 child sexual abusers), developmental experiences were recorded from a behavioral checklist, a parental-bonding survey, and a sexual history questionnaire. Offender classification was obtained from official records and verified through polygraph examinations.

Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis.

Psoriatic arthritis (PsA) is a chronic and erosive form of arthritis of unknown cause. We aimed to characterize the PsA phenotype using gene expression profiling and comparing it with healthy control subjects and patients rheumatoid arthritis (RA). Peripheral blood cells (PBCs) of 19 patients with active PsA and 19 age- and sex-matched control subjects were used in the analyses of PsA, with blood samples collected in PaxGene tubes.

Development and psychometric validation of a Domestic Violence Coping Self-efficacy Measure (DV-CSE).

Psychometric properties of a Domestic Violence Coping Self-Efficacy Measure were examined. Two-hundred eighty three women assaulted within the past 6 months were recruited. Internal reliability of the measure was very good (alpha = .

The relationship between trait vulnerability and anxiety and depressive diagnoses at long-term follow-up of Generalized Anxiety Disorder.

The current study examined the relationship between measures of trait vulnerability and long-term outcome in 83 patients diagnosed and treated for Generalized Anxiety Disorder (GAD) 8-14 years previously. Diagnostic status was assessed by structured interview, and trait affect, trait anxiety and trait depression were measured by the Positive and Negative Affect Scale (PANAS), the State-Trait Anxiety Inventory (STAI-T) and the Personal Style Inventory (PSI), respectively. Trait measures were all highly inter-correlated, and patients with diagnoses of GAD, social phobia and depressive disorders at long-term follow-up recorded very poor scores on all three scales.

Tayside-Fife clinical trial of cognitive-behavioural therapy for medication-resistant psychotic symptoms. Results to 3-month follow-up.

Background: Evidence for the efficacy of cognitive-behavioural therapy for schizophrenia is promising but evidence for clinical effectiveness is limited.

Aims: To test the effectiveness of cognitive-behavioural therapy delivered by clinical nurse specialists in routine practice.

Method: Of 274 referrals, 66 were allocated randomly to 9 months of treatment as usual (TAU), cognitive-behavioural therapy plus TAU (CBT) or supportive psychotherapy plus TAU (SPT) and followed up for 3 months.

Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice.

A key commonality of most age-related neurodegenerative diseases is the accumulation of aggregation-prone proteins in the brain. Except for the prionoses, the initiation and propagation of these proteopathies in vivo remains poorly understood. In a previous study, we found that the deposition of the amyloidogenic peptide Abeta can be induced by injection of dilute extracts of Alzheimeric neocortex into the brains of Tg2576 transgenic mice overexpressing the human beta-amyloid precursor protein.

The child sexual abuser: perceptions of college students and professionals.

College students and members of the Association for the Treatment of Sexual Abusers (ATSA) were compared as to their beliefs and attitudes concerning perpetrators of child sexual abuse. Analyses of a 44-item inventory (assessing beliefs about an abuser's demographics and attitudes concerning an abuser's cognitions and behaviors) indicated that the groups differed on perceived demographic descriptors (e.g.