Publications by authors named "Robert Dioszegi"
Article Synopsis
- Researchers developed new copper(II) complexes using pyridine-based ligands that have alanine and tyrosine to mimic superoxide dismutase (SOD) enzymes.
- These complexes were analyzed using various methods like UV-vis spectroscopy and X-ray diffraction, revealing they form stable structures that bind copper(II) effectively.
- The tyrosine-based complex showed higher activity in mimicking SOD due to its phenolic group, making it a promising candidate for medical applications.
A novel peptide conjugate (H(L2)) incorporating N-donors of the peptide backbone and an (O,O) donor set of a hydroxypyridinone moiety is synthesized and characterized. This ambidentate chelating ligand is intended to develop Co(iii)/Pt(ii) heterobimetallic multitargeted complexes with anticancer potential. To explore its metal ion binding ability the interaction with Pd(ii) (as a Pt(ii) model but with faster ligand exchange reactions) was studied in aqueous solution by the combined use of pH-potentiometry, NMR and HR MS.
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