Publications by authors named "Robert D Schlesinger"
Pulmonary capillary surface area in supine exercising humans: demonstration of vascular recruitment.
Am J Physiol Lung Cell Mol Physiol
September 2019
Article Synopsis
- The study investigates how cardiac output (CO) and pulmonary artery pressure (PAP) respond to exercise in humans, highlighting the mechanisms of capillary recruitment and distention during increased blood flow.
- It involved ten subjects undergoing exercise testing, with measurements showing significant increases in CO and PAP, while a decrease in the metabolism of a specific compound (BPAP) was observed at peak exercise.
- The results indicate that during moderate exercise, capillary recruitment is the primary response to increasing blood flow, whereas in one subject with already high CO, further increases were linked to capillary distention, providing insights into exercise physiology and pulmonary hypertension.
It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH.
View Article and Find Full Text PDFPhysicians often need to measure arterial PCO2 in clinical practice. Arterial blood gas sampling is typically available only in hospitals and may be unpleasant for patients. Minimally invasive techniques for measuring PCO2 offer the potential for overcoming these limitations.
View Article and Find Full Text PDFBackground: Maintenance of a favourable hemodynamic profile is central to therapeutic success in pulmonary arterial hypertension (PAH). There is little information about the safety of transitioning patients between oral therapies for PAH. Endothelin receptor antagonists (ERAs) have been a therapeutic mainstay in PAH, providing benefit to many patients.
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