Normal saline versus Normosol™-R in sepsis resuscitation: A retrospective cohort study.

Objective: To determine the effect of Normosol™-R as compared to normal saline on the outcomes of acute kidney injury and the need for renal replacement therapy in the resuscitation phase of sepsis.

Design: Our study is a retrospective before-and-after cohort study.

Setting: The study occurred at a 700-bed tertiary academic level 1-trauma center.

Conformational effects on the performance and selectivity of a polymeric pseudostationary phase in electrokinetic chromatography.

The effect of the conformation of a polymeric pseudostationary phase on performance and selectivity in electrokinetic chromatography was studied using an amphiphilic pH-responsive polymer that forms compact intramolecular aggregates (unimer micelles) at low pH and a more open conformation at high pH. The change in conformation was found to affect the electrophoretic mobility, retention, selectivity, and separation efficiency. The low-pH conformer has higher electrophoretic mobility and greater affinity for most solutes.