Publications by authors named "Robert D Boutin"

Article Synopsis
  • Opportunistic screening leverages existing CT imaging to diagnose osteoporosis without requiring extra tests for patients, addressing the healthcare burden of a condition that affects 500 million people worldwide.
  • While DXA is the standard method for osteoporosis diagnosis, many fractures occur in individuals who have never been screened, making CT a valuable tool due to its accessibility and ability to measure bone density.
  • The article discusses the advantages of using CT, including automation and the integration of radiomics and genomics, which may lead to better diagnosis, treatment options, and overall patient care in osteoporosis management.
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Article Synopsis
  • - Over 85 million CT scans are done annually in the US, with a significant portion focused on the abdomen, highlighting a need for efficient interpretation methods due to a shortage of radiologists.
  • - To address this, researchers introduced Merlin, a 3D Vision Language Model (VLM) that uses both electronic health records and radiology reports for training without the need for manual annotations, utilizing a vast clinical dataset of millions of images and codes.
  • - Merlin was evaluated on various tasks, including chronic disease prediction and report generation, showing better performance than current methods, demonstrating its potential to support radiologists in their work.
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  • - Myositis is an inflammation of skeletal muscle and falls under myopathy, which includes any muscle disorder; it can stem from autoimmune diseases, infections, or certain drugs.
  • - MRI is key for diagnosing myositis but can show similar features to other conditions, such as muscular dystrophies or injuries, which are called myositis mimics.
  • - The article aims to outline myositis' main characteristics, updates on idiopathic inflammatory myopathy (IIM), important MRI differentials, and future advancements like AI in diagnosing muscle disorders.
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MRI serves as a critical step in the workup, local staging, and treatment planning of extremity soft-tissue masses. For the radiologist to meaningfully contribute to the management of soft-tissue masses, they need to provide a detailed list of descriptors of the lesion outlined in an organized report. While it is occasionally possible to use MRI to provide a diagnosis for patients with a mass, it is more often used to help with determining the differential diagnosis and planning of biopsies, surgery, radiation treatment, and chemotherapy (when provided).

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Article Synopsis
  • Researchers developed and validated an open-source AI algorithm to detect different contrast phases in abdominal CT scans, using data from 739 exams across 200 patients.
  • The algorithm achieved high accuracy rates of 92.3% for internal testing and 90.1% for external validation, indicating strong performance in identifying non-contrast, arterial, venous, and delayed phases.
  • The study confirms the algorithm's effectiveness and potential for clinical applications, enhancing how medical professionals interpret CT scans for improved patient outcomes.
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Background: Deep learning facilitates large-scale automated imaging evaluation of body composition. However, associations of body composition biomarkers with medical phenotypes have been underexplored. Phenome-wide association study (PheWAS) techniques search for medical phenotypes associated with biomarkers.

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Article Synopsis
  • Chronic nonspinal osteomyelitis is difficult to diagnose and manage, prompting experts to create consensus statements on the use of percutaneous image-guided biopsies to improve standard care practices across different healthcare institutions.* -
  • MRI is an essential tool for ruling out osteomyelitis and should be performed early in patient evaluation; other microbiological culture methods can be used when conditions allow.* -
  • Expert recommendations include avoiding antibiotics for at least 2 weeks before a biopsy and advising against biopsies in cases of severe ulcers, emphasizing the need for a multidisciplinary approach in treatment.*
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Background: Sarcopenic obesity and muscle attenuation have been associated with survival in patients with borderline resectable and advanced pancreatic ductal adenocarcinoma (PDA); however, these relationships are unknown for patients with resectable PDA. This study examined the associations between skeletal muscle and adipose tissue as measured on baseline computed tomography (CT) and the overall survival (OS) of participants with resectable PDA in a secondary analysis of the Southwest Oncology Group S1505 clinical trial (identifier: NCT02562716).

Methods: The S1505 phase II clinical trial enrolled patients with resectable PDA who were randomized to receive modified FOLFIRINOX or gemcitabine and nab-paclitaxel as perioperative chemotherapy, followed by surgical resection.

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Article Synopsis
  • The significance of imaging biomarkers has grown in recent years, particularly in their clinical and research applications related to body composition.
  • Key imaging techniques such as dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging, and ultrasonography are used to assess bone, muscle, and fat tissues.
  • Understanding the specific terminology related to clinical and imaging practices is essential for effectively utilizing these biomarkers in health assessments.
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 Surgical procedure selection for carpal arthritis depends on which articular surfaces are affected, but there is no consensus on how to preoperatively evaluate cartilage surfaces. Despite advances in cross-sectional imaging, the utility of advanced imaging for preoperative decision-making has not been well established.  Our objective was to assess if there is an added value to presurgical advanced imaging or diagnostic procedures in planning for carpal arthrodesis or carpectomy and to determine what imaging or diagnostic procedures influence surgical treatment options.

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Objective: To systematically review the association of pain, function, and progression in first carpometacarpal (CMC) osteoarthritis (OA) with imaging biomarkers and radiography-based staging.

Design: Database searches in PubMed, Embase, and the Cochrane Library, along with citation searching were conducted in accordance with published guidance. Data on the association of imaging with pain, functional status, and disease progression were extracted and synthesized, along with key information on study methodology such as sample sizes, use of control subjects, study design, number of image raters, and blinding.

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  • Current risk scores for predicting ischemic heart disease (IHD) events are limited and could be improved with imaging biomarkers from CT scans.
  • A study involving 8,139 CT examinations developed automated models that integrate body composition features from imaging with electronic medical record data, outperforming existing clinical risk scores in some cases.
  • The research introduces a new method for understanding tissue-level contributions and provides the OL3I dataset to support further studies in predicting IHD using multimodal data.
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  • - The study focuses on optimizing the height scaling method used to assess sarcopenia (muscle loss) via the skeletal muscle index (SMI) by analyzing skeletal muscle area (SMA) from CT scans of 16,575 patients.
  • - Researchers conducted allometric analysis to determine the best height scaling powers for different age and sex groups, finding deviations from the traditional square height method that indicated better predictions of muscle mass.
  • - The findings suggested that using these newly derived scaling powers improved the SMI's ability to predict all-cause mortality, highlighting the importance of accurate muscle assessment in clinical settings.
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Objectives: Magnetic resonance imaging (MRI) using 1.5T or 3.0T systems is routinely employed for assessing wrist pathology; however, due to off-resonance artifacts and high power deposition, these high-field systems have drawbacks for real-time (RT) imaging of the moving wrist.

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Objective: To compare MRI features of medial and lateral patellar stabilizers in patients with and without patellar instability.

Methods: Retrospective study of 196 patients (mean age, 33.1 ± 18.

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Purpose: This study examines clinical, functional, and CT metrics of sarcopenia and all-cause mortality in older adults undergoing outpatient imaging.

Methods: The study included outpatients ≥ 65 years of age undergoing CT or PET/CT at a tertiary care institution. Assessments included screening questionnaires for sarcopenia (SARC-F) and frailty (FRAIL scale), and measurements of grip strength and usual gait speed (6 m course).

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The purpose of this article is to review steatosis and fibrosis of skeletal muscle, focusing on older adults. Although CT, MRI, and ultrasound are commonly used to image skeletal muscle and provide diagnoses for a variety of medical conditions, quantitative assessment of muscle steatosis and fibrosis is uncommon. This review provides radiologists with a broad perspective on muscle steatosis and fibrosis in older adults by considering the public health impact, biologic mechanisms, and evaluation with CT, MRI, and ultrasound.

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Rationale And Objectives: Tools are needed for frailty screening of older adults. Opportunistic analysis of body composition could play a role. We aim to determine whether computed tomography (CT)-derived measurements of muscle and adipose tissue are associated with frailty.

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Menisci play an essential role in maintaining normal pain-free function of the knee. While there are decades of MRI literature on the tears involving the meniscus body and horns, there is now a surge in knowledge regarding injuries at the meniscus roots and periphery. The authors briefly highlight new insights into meniscus anatomy and then summarize recent developments in the understanding of meniscus injuries that matter, emphasizing meniscus injuries at the root and peripheral (eg, ramp) regions that may be missed easily at MRI and arthroscopy.

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Article Synopsis
  • Patellofemoral pain and instability are common problems that doctors often need to check with images to see what's going on in the knee.
  • The main focus is on the medial patellofemoral ligament (MPFL), which helps keep the kneecap in place, and sometimes needs surgery if it doesn’t work right.
  • Radiologists use different types of imaging like X-rays and MRIs to figure out how the kneecap is aligned and if there are any issues, and treatment can be either non-surgical or surgical depending on the situation.
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Volumetric ultrasound imaging has the potential for operator-independent acquisition and enhanced field of view. Panoramic acquisition has many applications across ultrasound; spanning musculoskeletal, liver, breast, and pediatric imaging; and image-guided therapy. Challenges in high-resolution human imaging, such as subtle motion and the presence of bone or gas, have limited such acquisition.

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Objectives: The purpose of this agreement was to establish evidence-based consensus statements on imaging of distal radioulnar joint (DRUJ) instability and triangular fibrocartilage complex (TFCC) injuries by an expert group using the Delphi technique.

Methods: Nineteen hand surgeons developed a preliminary list of questions on DRUJ instability and TFCC injuries. Radiologists created statements based on the literature and the authors' clinical experience.

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Ageism is an increasingly recognized form of cognitive bias involving stereotypes, prejudice, and discrimination directed toward people on the basis of their age. Age-based bias influences how medicine is practiced and can result in profoundly negative but avoidable health outcomes. Awareness and education regarding ageism and its manifestations can improve the ability to identify and mitigate ageism.

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