Publications by authors named "Robert Crookston"
Article Synopsis
- The UK islet allotransplant program aims to provide islet transplants for individuals with type 1 diabetes and severe hypoglycemia, allowing for one or two transplants annually.
- A study of 84 transplant recipients found that those receiving two transplants had significantly better graft survival at 12 months compared to those who had one transplant (94% vs. 68%).
- Total transplanted mass didn't lead to significantly higher stimulated C-peptide levels, but a shorter time between two transplants was linked to greater insulin dose reductions after 12 months.*
Article Synopsis
- The study investigates the psychological burden and hypoglycemia awareness in UK islet transplant recipients, focusing on how these factors correlate with baseline HbA1c levels.
- Pre-transplant assessments revealed that participants experienced significant anxiety/depression, impaired quality of life, and elevated fear of hypoglycemia, yet maintained optimism about the potential benefits of the transplant.
- Results indicated that psychological profiles and hypoglycemia awareness did not differ significantly between groups with lower and higher HbA1c levels, suggesting that these psychological factors are prevalent regardless of glycemic control.
Tamoxifen, a breast cancer drug, has recently been approved for the chemoprevention of this disease. However, tamoxifen causes hepatic carcinomas in rats through a genotoxic mechanism and increases the risk of endometrial tumors in women. DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage plays a role in tamoxifen-induced endometrial carcinogenesis.
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