Publications by authors named "Robert C Will"
Cholera is a life-threatening infectious disease that remains an important public health issue in several low and middle-income countries. In 1992, a newly identified O139 Vibrio cholerae temporarily displaced the O1 serogroup. No study has been able to answer why the potential eighth cholera pandemic (8CP) causing V.
View Article and Find Full Text PDFWe investigated the evolution, phylogeny and antimicrobial resistance of O1 isolates (VCO1) from Ghana. Outbreak and environmental sources of VCO1 were characterized, whole-genome sequenced and compared to globally available seventh pandemic (7P) strains of at SNP resolution. Final analyses included 636 isolates.
View Article and Find Full Text PDFArticle Synopsis
- Diphtheria is caused by the bacterium Corynebacterium diphtheriae, and despite a successful vaccine introduced in the 1930s, cases have been on the rise in recent years.
- A study of 502 isolates from 16 countries over 122 years revealed diverse clusters of the bacteria and significant findings regarding antimicrobial resistance genes.
- Researchers identified 18 variants of the tox gene, with many mutations showing medium to high structural impact, suggesting increased complexity and potential health risks.