Effects of hydroxyflutamide in the medial preoptic area or lateral septum on reproductive behaviors in male rats.

We examined whether androgen receptors in the medial preoptic area (MPOA) and lateral septum (LS) are required for the expression of copulation and sexual motivation. Castrated males received testosterone-filled silastic capsules to restore behavior, and were implanted with the antiandrogen hydroxyflutamide (OHF) or blank cannulae. One group was implanted in either the anteroventral MPOA or LS (ANT group).