Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging.

Background: Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA1) graphical models to the standard one-tissue-compartment (1TC) model, including correction for partial-volume effects, in dynamic PET-CT studies of myocardial sympathetic innervation in the left ventricle (LV) using [C]HED.

Methods: Test and retest [C]HED PET imaging (47 ± 22 days apart) was performed in 18 subjects with heart failure symptoms.

Image-Guided Neurosurgery.

Image-guided surgery provides more precise targeting, is less invasive, and has improved outcomes when compared with conventional surgical approaches. Imaging is used to plan, monitor progress, and assess results. Because no one modality offers real-time physiological and anatomical information, a wide range of imaging modalities are used at each phase of the surgery.