Liraglutide treatment in overweight and obese patients with type 1 diabetes: A 26-week randomized controlled trial; mechanisms of weight loss.

Aim: To investigate the effects of liraglutide treatment on glycaemic control and adipose tissue metabolism in overweight and obese people with type 1 diabetes (T1DM).

Research Design And Methods: A total of 84 adult overweight and obese patients with T1DM, with no detectable C-peptide, were randomized (1:1) to either placebo or 1.8 mg/d liraglutide for 6 months.

Novel entry to the synthesis of ()- and ()-5-methoxycarbonylhydroxymethyluridines - a diastereomeric pair of wobble tRNA nucleosides.

Two novel methods for the preparation of the virtually equimolar mixtures of ()- and ()-diastereomers of 5-methoxycarbonylhydroxymethyluridine (mchmU) have been developed. The first method involved α-hydroxylation of a 5-malonate ester derivative of uridine (5) with SeO, followed by transformation to ()- and ()-5-carboxymethyluridines (cmU, 8) and, finally, into the corresponding methyl esters. In the second approach, ()- and ()-mchm-uridines were obtained starting from 5-formyluridine derivative (9) by hydrolysis of the imidate salt (11) prepared in the acid catalyzed reaction of 5-cyanohydrin-containing uridine (10b) with methyl alcohol.