Publications by authors named "Robert Au Baumgartner"
JCI Insight
September 2021
Article Synopsis
- cGMP-dependent protein kinase 1α (PKG1α) supports heart function in response to pressure overload, but its activation often leads to hypotension, which limits its therapeutic use in heart failure.*
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- The study found that mixed lineage kinase 3 (MLK3) interacts with PKG1α and is crucial for maintaining left ventricle (LV) function without affecting blood pressure (BP), even in conditions of heart failure.*
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- Results indicate that enhancing MLK3 activity could help improve heart function in heart failure patients while preventing the drop in blood pressure typically associated with PKG1α activation.*
