Competitive cation binding computations of proton balance for reactions of the phosphagen and glycolytic energy systems within skeletal muscle.

Limited research and data has been published for the H+ coefficients for the metabolites and reactions involved in non-mitochondrial energy metabolism. The purpose of this investigation was to compute the fractional binding of H+, K+, Na+ and Mg2+ to 21 metabolites of skeletal muscle non-mitochondrial energy metabolism, resulting in 104 different metabolite-cation complexes. Fractional binding of H+ to these metabolite-cation complexes were applied to 17 reactions of skeletal muscle non-mitochondrial energy metabolism, and 8 conditions of the glycolytic pathway based on the source of substrate (glycogen vs.

Lessons from Popper for science, paradigm shifts, scientific revolutions and exercise physiology.

A connection has been made to the possible role of the central governor model (CGM) to be a paradigm shift within the exercise sciences. Unfortunately, very little evidence was presented to support this notion, and a narrow view of scientific philosophy was used to reflect on the role of the CGM in understanding exercise physiology and the pursuit of a more ideal scientific method. When contrasting the scientific philosophies of Kuhn to Popper, and applying the tenant of falsification to the research and commentary on the CGM, it is probable that the scholarship pertaining to the CGM adheres more to pseudoscience than science.

Open-ended time durations for stationary start intense cycle ergometer exercise testing.

The study involved application of different applied loads to measure altered test durations, time to peak power, peak power, and peak cadence during intense cycle ergometry exercise. Healthy, physically active male (n = 11) and female (n = 11) subjects (18-45 years) performed the following 3 bouts of intense cycle ergometry at peak cadence to volitional exhaustion on 3 separate days, 48 h to 1 week apart: (i) 85 g·kg(-1) body mass load; (ii) 75 g·kg(-1) body mass load; and (iii) 100 g·kg(-1) body mass load. Trials (ii) and (iii) were performed in random order after trial (i).

Validation of a new mixing chamber system for breath-by-breath indirect calorimetry.

Limited validation research exists for applications of breath-by-breath systems of expired gas analysis indirect calorimetry (EGAIC) during exercise. We developed improved hardware and software for breath-by-breath indirect calorimetry (NEW) and validated this system as well as a commercial system (COM) against 2 methods: (i) mechanical ventilation with known calibration gas, and (ii) human subjects testing for 5 min each at rest and cycle ergometer exercise at 100 and 175 W. Mechanical calibration consisted of medical grade and certified calibration gas ((4.