Publications by authors named "Robert A Sommer"
Article Synopsis
- Cell growth is essential for cells to progress through the cell cycle, and nutrient availability affects how much growth is needed.
- In budding yeast, poor nutrients lead to smaller cell sizes, and researchers identified proteins that influence bud growth using mass spectrometry.
- The study discovered that nutrients regulate components of the mitotic exit network (MEN), which ensures that cells exit mitosis only after adequate bud growth has occurred.
Entry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5. Growth-dependent changes in the concentrations of Cln3 or Whi5 have been proposed to link cell cycle entry to cell growth.
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