Publications by authors named "Robert A Heegel"
Article Synopsis
- The Systems Biology for Infectious Diseases Research program was created by the U.S. National Institute of Allergy and Infectious Diseases to study how hosts and pathogens interact on a systems level, primarily focusing on viral infections.
- The program produced 47 datasets from various studies, examining responses to severe viruses such as pandemic H1N1, avian H5N1, and SARS-CoV, with validation through quality control and meta-analysis.
- Key data and results are accessible publicly through repositories like GEO and PeptideAtlas, and tools for further research are available at the Influenza Research Database and Virus Pathogen Resource for scientists to explore viral infection responses.
Article Synopsis
- Respiratory infections from influenza and SARS-CoV pose serious public health risks, yet effective therapies targeting these infections are lacking.
- The study uses an integrated approach combining proteome and transcriptome data from human lung cells infected with these viruses to predict key regulatory genes involved in the host's response.
- By employing a "crowd-based" method and multivariate regression, the researchers identified a set of regulatory factors that could be crucial for viral pathogenesis and potential therapeutic targets across various respiratory virus models.
