Targeted phage hunting to specific clinical isolates is an efficient antibiotic resistance and infection control strategy.

is one of the most threatening multi-drug-resistant pathogens today, with phage therapy being a promising alternative for personalized treatments. However, the intrinsic capsule diversity in spp. poses a substantial barrier to the phage host range, complicating the development of broad-spectrum phage-based treatments.

DepoScope: Accurate phage depolymerase annotation and domain delineation using large language models.

Bacteriophages (phages) are viruses that infect bacteria. Many of them produce specific enzymes called depolymerases to break down external polysaccharide structures. Accurate annotation and domain identification of these depolymerases are challenging due to their inherent sequence diversity.

Broad-range capsule-dependent lytic against sp.

The emergence of multi-drug resistant bacteria is a global health problem. Among them, is considered a high-priority pathogen, making it necessary to develop new therapeutic tools to reduce the bacterial burden in an effective and sustainable manner. Phages, bacterial viruses, are very promising tools.