Publications by authors named "Robbers-Visser D"
Background: Resveratrol, a dietary supplement that intervenes in cellular metabolism, has been shown to reduce aortic growth rate in a mouse model of Marfan syndrome (MFS), a condition associated in humans with life-threatening aortic complications, often preceded by aortic dilatation. The primary objective of this study was to investigate the effects of resveratrol on aortic growth rate in patients with MFS .
Methods: In this investigator-initiated, single-arm open-label multicentre trial, we analysed resveratrol treatment in adults aged 18-50 years with MFS.
Article Synopsis
- Young patients with cryptogenic stroke and a patent foramen ovale (PFO) sometimes receive device closure to prevent future strokes, but about 25% may still have a residual right-to-left shunt after 6 months.
- In a study of 227 patients, it was found that at 6 months post-closure, 72.7% had no shunt, while the rest had varying degrees of residual shunt.
- By 12 months, many of these residual shunts had either diminished or closed completely, indicating that while residual shunts are common at 6 months, most are small and tend to close over time.
Article Synopsis
- Increasing survival rates in adults with congenital heart disease (ACHD) lead to complications like arrhythmias and heart failure; therefore, transcatheter valve interventions are emerging as a viable treatment option.
- A study at the Center of Congenital Heart Disease Amsterdam-Leiden analyzed ACHD patients with severe atrioventricular (AV) valve regurgitation who underwent various transcatheter procedures from 2020 to 2022, noting improvements in condition without complications.
- The findings suggest that while transcatheter valve repair can be safe and effective for complex ACHD patients, ongoing collaboration and individualized treatment strategies from a dedicated heart team are crucial for optimizing outcomes and future evaluations are needed to assess long-term results.
Article Synopsis
- Cardiovascular disease is the leading cause of death in women, and understanding its risk factors, including the connection between preeclampsia and spontaneous preterm birth (SPTB), is crucial for prevention.
- The study assessed women with a history of SPTB against controls with term births, finding that while LV diastolic function parameters were generally similar, those with SPTB and hypertension exhibited notable changes.
- The results suggest that hypertension after SPTB may exacerbate alterations in heart function, highlighting the need for monitoring women's cardiovascular health post-pregnancy.
Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV.
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- - The study aimed to evaluate whether low-dose dobutamine stress echocardiography (DSE) can predict residual mitral regurgitation (MR) after transcatheter edge-to-edge mitral valve repair (TMVR) procedures.
- - Findings showed that among 39 patients, those who experienced an increase in MR during DSE were more likely to have significant residual MR at discharge, highlighting DSE's predictive value.
- - The high sensitivity (100%) and specificity (85%) of DSE make it a powerful tool for guiding clinical decisions post-TMVR, potentially leading to better patient outcomes.
Article Synopsis
- The ESC guidelines recommend screening for arrhythmic events in patients with adult congenital heart disease (ACHD), but the best detection method is unclear.
- A study compared two methods of monitoring arrhythmias in ACHD patients: implantable loop recorders (ILRs) and smartphone-based single-lead electrocardiograms, involving a total of 116 patients.
- Findings showed that both methods had similar effectiveness in detecting arrhythmias, with smartphone monitoring being a viable, non-invasive alternative, particularly for patients without syncope.
Background: Anomalous coronary artery from the pulmonary artery is a rare congenital disorder with high mortality rates in infancy. Adult cases can present with life-threatening arrhythmias and sudden cardiac death.
Case Summary: We report three cases of adults with anomalous pulmonary origin of each of the main coronary branches.
Background: Various electrocardiogram (ECG)-based devices are available for home monitoring, but the reliability in adults with CHD is unknown. Therefore, we determined the accuracy of different ECG-based devices compared to the standard 12-lead ECG in adult CHD.
Methods And Results: This is a single-centre, prospective, cross-sectional study in 176 consecutive adults with CHD (54% male, age 40 ± 16.
Background: Patients undergoing invasive cardiothoracic procedures are prone for pre-procedural anxiety and depression. Patient education is known to reduce anxiety. This study was performed to assess the effect of Virtual Reality (VR) as a means to educate patients to reduce pre-procedural anxiety in adult patients undergoing percutaneous closure of a patent foramen ovale (PFO) or atrial septal defect (ASD).
View Article and Find Full Text PDFBackground: In response to an increased need for patient information in congenital heart disease, we previously developed an online, evidence-based information portal for patients with congenital aortic and pulmonary valve disease. To assess its effectiveness, a stepped-wedge cluster randomised trial was conducted.
Methods: Adult patients and caregivers of paediatric patients with congenital aortic and/or pulmonary valve disease and/or tetralogy of Fallot who visited the outpatient clinic at any of the four participating centres in the Netherlands between 1 March 2016-1 July 2017 were prospectively included.
Background: Sudden cardiac death (SCD) is the main preventable cause of death in patients with adult congenital heart disease (ACHD). Since robust risk stratification methods are lacking, we developed a risk score model to predict SCD in patients with ACHD: the PRospEctiVE study on implaNTable cardIOverter defibrillator therapy and suddeN cardiac death in Adults with Congenital Heart Disease (PREVENTION-ACHD) risk score model.
Objective: The purpose of this study was to prospectively study predicted SCD risk using the PREVENTION-ACHD risk score model and actual SCD and sustained ventricular tachycardia/ventricular fibrillation (VT/VF) rates in patients with ACHD.
Objectives: The aim of this study was to determine the course of tricuspid regurgitation (TR) after transcatheter mitral valve repair (TMVR), identify predictors for severe TR after TMVR and determine the association of severe TR after TMVR with outcome.
Background: TR is often present in patients with symptomatic mitral regurgitation (MR) and is associated with increased morbidity and mortality. The clinical course of TR after TMVR has not been clearly determined.
Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations.
Eur Heart J Cardiovasc Pharmacother
January 2022
Aims: Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements.
View Article and Find Full Text PDFBackground: Adults with congenital heart disease (ACHD) often suffer from deterioration related to cardiac arrhythmias, hypertension (HT) or heart failure (HF), frequently occurring between planned visits. Mobile health (mHealth) could improve management through remote monitoring by enabling swift therapeutic response and detecting new diagnoses.
Methods: We performed a prospective study employing mHealth in ACHD patients, weekly monitoring heart rhythm, weight and blood pressure.
A 73-year old man presented with a posterolateral ST-elevated myocardial infarction 9 months after biological aortic valve replacement for aortic valve stenosis. Invasive coronary angiography showed a filling defect across the left main coronary artery bifurcation extending into the left anterior descending artery and the ramus circumflex. Transthoracic echocardiography revealed a thickened prosthesis leaflet with signs of slight stenosis.
View Article and Find Full Text PDFAims: Cardiovascular magnetic resonance (CMR) imaging is an important tool in the assessment of paediatric cardiac disease. Reported reference values of ventricular volumes and masses in the paediatric population are based on small cohorts and several methodologic differences between studies exist. We sought to create steady-state free precession (SSFP) CMR reference values for biventricular volumes and mass by combining data of previously published studies and re-analysing these data in a standardized manner.
View Article and Find Full Text PDFStaged total cavopulmonary connection: serial comparison of intra-atrial lateral tunnel and extracardiac conduit taking account of current surgical adaptations.
Interact Cardiovasc Thorac Surg
September 2019
Objectives: Our goals were to compare the outcome of the intra-atrial lateral tunnel (ILT) and the extracardiac conduit (ECC) techniques for staged total cavopulmonary connection (TCPC) and to compare the current modifications of the TCPC technique, i.e. the prosthetic ILT technique with the current ECC technique with a ≥18-mm conduit.
View Article and Find Full Text PDFBackground: Arrhythmias and heart failure are common and invalidating sequelae in adult patients with congenital heart disease (CHD). Mobile health (m-Health) enables daily monitoring and a timely response that might prevent deterioration. We present an observational prospective registry to evaluate feasibility of an m‑Health telemonitoring program for managing arrhythmia, heart failure and blood pressure in symptomatic adults with CHD.
View Article and Find Full Text PDFBackground: Use of 4-dimensional flow magnetic resonance imaging (4D-flow MRI) derived wall shear stress (WSS) heat maps enables identification of regions in the ascending aorta with increased WSS. These regions are subject to dysregulation of the extracellular matrix and elastic fiber degeneration, which is associated with aortic dilatation and dissection.
Purpose: To evaluate the effect of the presence of aortic valve stenosis and the aortic diameter on the peak WSS and surface area of increased WSS in the ascending aorta.