Publications by authors named "Robbe Tanghe"
Article Synopsis
- Cadmium is a toxic metal that can cause cancer, but its specific mechanisms of toxicity are not fully understood.
- The study shows that cadmium causes certain proteins in living cells to clump together, particularly those that are still being made or folded.
- The aggregation of these proteins can lead to further misfolding, contributing to cadmium's harmful effects and potentially linking it to diseases related to protein folding.
Next-generation sequencing (NGS) has been applied successfully to the field of therapeutic antibody discovery, often outperforming conventional screening campaigns which tend to identify only the more abundant selective antibody sequences. We used NGS to mine the functional nanobody repertoire from a phage-displayed camelid immune library directed to the recepteur d'origine nantais (RON) receptor kinase. Challenges to this application of NGS include accurate removal of read errors, correct identification of related sequences, and establishing meaningful inclusion criteria for sequences-of-interest.
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