Publications by authors named "Robb M"

A globally effective vaccine will need to elicit cytotoxic T lymphocytes (CTL) capable of recognizing diverse human immunodeficiency virus type 1 (HIV-1) clades. Study of the cellular immune responses of HIV-1-infected persons may allow predictions to be made regarding useful vaccine antigen components. The frequency and magnitude of CTL responses to clade E and B Gag, Pol-RT, Env, and Nef proteins were compared in 12 HLA-characterized, clade E-infected Thais and in 10 clade B-infected North Americans using vaccinia recombinant constructs for protein expression.

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Human immunodeficiency virus (HIV)-1-infected rapid and slow progressors showed differential humoral responses against HIV envelope peptides and proteins early in infection. Sera from slow progressors reacted more strongly with short envelope peptides modeling gp160NL4-3, predominantly in gp41. Reactivity to six peptides (in constant regions C3, C4, and C5 of gp120 and in gp41) correlated with slower progression.

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Inferences were made regarding vocal tract vowel space during fluently produced utterances through examination of the first two formant frequencies. Fifteen adult males served as subjects, representing separate groups of untreated and treated individuals who stutter and nonstuttering controls. The steady-state portion of formant one (F1) and formant two (F2) was examined in the production of various CVC tokens containing the vowels /i/, /u/, and /a/.

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Adipose tissue is an important site of cholesteryl ester transfer protein (CETP) synthesis and CETP plays a local role in adipocyte cholesteryl ester accumulation from high density lipoproteins (HDL). Human adipose tissue maintained in organ culture secretes CETP, but it is not known to what extent adipose tissue CETP contributes to the plasma pool of CETP in man. Aging is associated with changes in adipose tissue composition and function, including impaired adipocyte triglyceride lipolysis.

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Within a multivariate design, the relationship between sex, sport, and competitive situation with state anxiety was examined. The Competitive State Anxiety Inventory-2 was administered to selected intramural basketball and volleyball teams (ns = 266 and 226) prior to round-robin and play-off competition. Multivariate analysis of variance yielded a significant interaction of sport by sex and a significant main effect for sport.

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Cholesteryl ester transfer protein (CETP) mRNA is more abundantly expressed in small mature adipocytes as compared to large, lipid-rich adipocytes [Radeau et al., J. Lipid Res.

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Objective: To propose a model for teaching and supervising the termination process in psychoanalytic psychotherapy.

Method: Group supervision of the 12-week termination phase of psychotherapy with a patient who had been in psychotherapy with a senior resident for 2 years.

Results: This supervisory method provided a positive termination experience for the patient and valuable group-teaching experience for residents at various levels in their training.

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Current economic and fiscal imperatives in health care demand innovative and cost-effective methods of care delivery. At St. Joseph's Health Centre in London, Ontario since 1990 we have been pioneering the process of dialyzer re-use in order to reduce costs while maintaining quality care.

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Vocal tract acoustic resonance was evaluated in a group of 10 untreated adult males with diagnosed obstructive sleep apnea (OSA) syndrome compared to 10 non-OSA adult males. Subjects were required to prolong the vowels /i/, /u/ and /a/, which were subsequently submitted to acoustic analysis of formant frequency and formant bandwidth. Results of the formant frequency analysis indicated lower formant values among the OSA group compared to the non-OSA group, for each vowel type.

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Three antibody reagents that neutralize primary human immunodeficiency virus type 1 (HIV-1) isolates were tested for magnitude and breadth of neutralization when used alone or in double or triple combinations. Hyperimmune anti-HIV immunoglobulin (HIVIG) is derived from the plasma of HIV-1-infected donors, and monoclonal antibodies (MAbs) 2F5 and 2G12 bind to distinct regions of the HIV-1 envelope glycoprotein. The antibodies were initially tested against a panel of 15 clade B HIV-1 isolates, using a single concentration that is achievable in vivo (HIVIG, 2,500 microg/ml; MAbs, 25 microg/ml).

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Developmental characteristics of formant 1 (F1) and formant 2 (F2) are reported for spontaneous vocalizations produced by four young children. Each child was systematically sampled at between 15 and 36 months of age. Results indicated that both F1 and F2 remained relatively unchanged prior to 24 months of age.

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CAS-MCSCF calculations describe the addition of singlet CF(2) and C(OH)(2) to the ethene double bond as a two-step reaction. The energy barriers that separate, in the first rate-determining step, loosely bound pi-complexes from stable CH(2)CH(2)CX(2) diradical intermediates show the expected ordering, smaller for CF(2) than for C(OH)(2). Back-dissociation of the diradicals into reactants requires the overcoming of non-negligible energy barriers.

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Because mucosal immune responses may be important in protection against human immunodeficiency virus type 1 (HIV-1), HIV-1-specific immune responses at mucosal sites in natural infection were compared. Total antibody concentrations and HIV-1-specific binding antibody responses in four distinct mucosal sites and serum were assessed in 41 HIV-infected and 19 HIV-seronegative women. HIV-1 gp160-specific IgG responses were detected in >99% of mucosal samples in infected subjects, with the highest titers in genital secretions.

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Average formant frequency and formant bandwidth values are reported in a cross-sectional sample of 20 children between 4 and 25 months of age. With the exception of a slight rise in F1 at 18 months of age, average F1 and F2 values changed little during the time period, while the average bandwidths for F1 (B1) and F2 (B2) were found to significantly decrease as age increased. The pattern observed for both average formant frequencies and formant bandwidths were attributed to developmental reconfiguration of the vocal tract.

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The durational characteristics of 10 normal infant's complete crying episodes are reported. The cries of each child were audiorecorded at 2 days postpartum and acoustically analyzed for overall occurrence of expiratory cry segments, inspiratory cry segments, and nonphonatory 'pause' segments. In general, remarkable similarity was found across infants with regard to the distributional occurrence of the cry features.

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The durational characteristics of crying episodes produced among two groups of at-risk newborn infants are reported. The groups included preterm infants with diagnosed respiratory problems and preterm infants with diagnosed neurological problems. Each infant's complete crying episode was audio-recorded and acoustically analyzed for overall occurrence of expiratory cry segments, inspiratory cry segments, and nonphonatory 'pause' segments.

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The amount of human immunodeficiency virus (HIV) type 1 RNA and the presence of a codon 215 mutation indicative of zidovudine resistance were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n = 25; median, 430 copies/mL; range, 0-2.2 x 10(5) copies/mL) followed by the moderately encephalopathic (n = 7; median, 330; range, 0-1130) and nonencephalopathic groups (n = 9; median, 0; range, 0-566) (P = .

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Objective: To evaluate whether pediatric patients infected with human immunodeficiency virus (HIV) can mount appropriate delayed-type hypersensitivity (DTH) skin responses to recall antigens and whether these responses can be correlated with clinical or immunologic parameters.

Design: Prospective evaluation of DTH responses in HIV-infected children. Uninfected children born to HIV-infected mothers served as control subjects.

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Ochrobactrum anthropi is a nonfermentative gram-negative bacillus that has been isolated with increasing frequency from human clinical specimens. Previously, its pathogenic niche was believed to involve the causation of catheter-associated bacteremic illnesses. We describe three cases of pyogenic infection due to O.

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The vocal fundamental frequency (Fo) characteristics of four infants' hunger cries are reported. The infants were audio recorded at monthly intervals during the first year of life. In general, each infant's Fo increased across the one-year period.

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A recombinant plasmid, pArab8, harbouring the cDNA encoding the mature form of the tetrapyrrole synthesis enzyme porphobilinogen deaminase (EC 4.3.1.

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Cholesteryl ester transfer protein (CETP) has a well-defined role in plasma neutral lipid transport. CETP synthesized by human adipose tissue may contribute to the plasma CETP pool. CETP mRNA abundance increases in subcutaneous adipose tissue in response to cholesterol feeding and we have hypothesized that CETP gene expression is regulated by a specific pool of cellular sterol.

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