[The role of matrix metalloproteinases in tumor invasion and metastasis].

The complicated process of invasion and metastasis consists of a long series of sequential and interrelated steps. The outcome of the process is dependent on both: the tumour cells and the properties of tissue microenvironments. Many investigators are interested in the influence of extracellular matrix components on that process.

[Intrauterine fetal death at term--imperfection of medical supervision methods or statistical-biological inevitability--attempt for discussion based on a case report].

There is a description of the case of unexplained intrauterine fetal death at term. The course of the pregnancy was regular. There were any sinister symptoms preceded and there were no malformations or other abnormalities observed thereafter.

[Cytotoxic activity of NK cells in the presence of the peritoneal fluid fro women with unexplained infertility and with endometriosis related infertility].

We examined peritoneal fluid obtained during laparoscopy in the aspect of its influence on cytotoxic activity of NK cells. We showed significant suppression of this activity in women with unexplained infertility. The suppression of NK activity was also present in women fertile and infertile both, with severe endometriosis.

[Level of endothelin-1,2,6-keto-pgf1-alpha and atrial natriuretic peptide in serum of pregnant women with late hypertension].

Unlabelled: The etiology of late hypertension (LH) in pregnant women is still unknown. The purpose of this study was to measure the circulatory levels of endothelin-1,2 (ET-1,2), 6-keto-PGF1-alfa as a major metabolite of prostacyclin, and atrial natriuretic peptide (ANP) in the serum of pregnant women with LH, and in the serum of control healty pregnant women, and control healthy nonpregnant women.

Results: The mean level of ET-1,2 among pregnant women with LH did not show any significant difference compared to control group.

[Prenatal trauma of newborns from labor with pelvic presentation in the I Obstetric Clinic Medical Academy in Wrocław in the years 1946-1990].

The analysis of 2191 labours with pelvic presentation indicated that most perinatal traumas of newborns occurred after manual extraction of the fetus, and least frequent injuries were in children delivered by caesarean section. Within the period of 45 years (1946-1990) a statistically significant decrease occurred of the number of perinatal trauma of newborns which was proportional to an increase of the number of labours terminated with caesarean section.

[Treatment of anemia in pregnant women with an animal blood preparation, "Livex"].

The animal blood preparation Livex obtained from the Agricultural Academy in Wrocław was used for treatment of anaemia of pregnancy. During four weeks of treatment (3 x 7.0 g of Livex added to diet) a statistically significant increase was found of anaemia parameters such as haemoglobin level, value of haematocrit, red blood cell count, and mean corpuscular volume.

[Personal experience with obstetric care of diabetic pregnant women].

The authors, basing in the survey of literature and on own experience, discuss pregnancy in diabetic patients together with possible complications. Pregnancy exerts an unfavourable effect on diabetes mellitus with significant vascular disorders being in some cases even life-threatening. An of clinical status of the diabetes mellitus should be always carefully assessed in every diabetic woman to avoid serious complications, which may occur later-during possible pregnancy.

[Insulin daily dose and body weight of neonates delivered by diabetic mothers].

Dependence of birth weight on insulin dosage in pregnant diabetic women, diabetes mellitus class (according to White) have been discussed. An analysis included 56 pregnancies complicated with diabetes mellitus, which were terminated at the I Department of Obstetrics, Medical Academy in Wrocław between January, 1981 and January, 1988. Neonates birth weight is reversely proportional to insulin daily dose given to pregnant women diabetes mellitus during the III trimester of pregnancy.

[Sodium outflow rate through lymphocyte cellular membranes in women with arterial hypertension caused by pregnancy and in health pregnant women].

Ouabain- and furosemide-dependent rate of sodium outflow through lymphocytes cellular membranes was measured in both healthy pregnant women and those with arterial blood hypertension caused by pregnancy. It was shown, that ouabain-dependent sodium outflow rate is decreased in healthy women in the I, II, and III trimester of pregnancy, while in women with arterial hypertension in the III trimester. No difference in sodium outflow rate both total and furosemide-dependent in healthy pregnant women during the I, II and III trimester, and in pregnant women with arterial hypertension due to pregnancy in the III trimester was noted.

[Neonatal complications in infants born to mothers with diabetes mellitus].

Health status of 53 babies delivered by diabetic mothers are discussed. Neonatal period was uncomplicated only in 12 cases. The remaining babies suffered from respiratory disorders, edema, neurological disturbances, prolonged jaundice, infections etc.

[Prune belly syndrome of Obrinsky in a newborn infant].

A rare case of the prune syndrome of Obrinsky was observed in a male newborn born in pelvic presentation in poor condition. The newborn died during operation for cord hernia and suturing of the perforated persisting urachus with signs of cardiorespiratory failure.

[Acute renal failure in neonates and infants].

Causes, course and prognosis in 90 cases of the acute renal failure in neonates and infants have been discussed. All cases were treated between 1971 and 1985. Recently, an increase in the incidence of the acute renal failure is being noted.