Publications by authors named "Rob P Igo"
Article Synopsis
- - The study focuses on using genome-wide association studies to analyze related traits for primary open-angle glaucoma (POAG), particularly looking at optic nerve head (ONH) parameters like cup area and disc area.
- - It identifies new genetic variants linked to ONH traits that have significant implications for POAG, and these variants have been confirmed in independent Asian cohorts.
- - However, the validation of these findings is complicated due to the diversity within POAG groups, suggesting that multi-trait analysis is an effective method for discovering new genetic factors.
Importance: Genetic variants associated with primary open-angle glaucoma (POAG) are known to influence disease risk. However, the clinical effect of associated variants individually or in aggregate is not known. Genetic risk scores (GRS) examine the cumulative genetic load by combining individual genetic variants into a single measure, which is assumed to have a larger effect and increased power to detect relevant disease-related associations.
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